Damiri Fouad, Rahman Md Habibur, Zehravi Mehrukh, Awaji Aeshah A, Nasrullah Mohammed Z, Gad Heba A, Bani-Fwaz Mutasem Z, Varma Rajender S, Germoush Mousa O, Al-Malky Hamdan S, Sayed Amany A, Rojekar Satish, Abdel-Daim Mohamed M, Berrada Mohammed
Labortory of Biomolecules and Organic Synthesis (BioSynthO), Department of Chemistry, Faculty of Sciences Ben M'Sick, University Hassan II of Casablanca, Casablanca 20000, Morocco.
Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon, Korea.
Materials (Basel). 2022 Feb 23;15(5):1666. doi: 10.3390/ma15051666.
Polymeric nanocomposites have been outstanding functional materials and have garnered immense attention as sustainable materials to address multi-disciplinary problems. MXenes have emerged as a newer class of 2D materials that produce metallic conductivity upon interaction with hydrophilic species, and their delamination affords monolayer nanoplatelets of a thickness of about one nm and a side size in the micrometer range. Delaminated MXene has a high aspect ratio, making it an alluring nanofiller for multifunctional polymer nanocomposites. Herein, we have classified and discussed the structure, properties and application of major polysaccharide-based electroactive hydrogels (hyaluronic acid (HA), alginate sodium (SA), chitosan (CS) and cellulose) in biomedical applications, starting with the brief historical account of MXene's development followed by successive discussions on the synthesis methods, structures and properties of nanocomposites encompassing polysaccharides and MXenes, including their biomedical applications, cytotoxicity and biocompatibility aspects. Finally, the MXenes and their utility in the biomedical arena is deliberated with an eye on potential opportunities and challenges anticipated for them in the future, thus promoting their multifaceted applications.
聚合物纳米复合材料一直是出色的功能材料，并作为解决多学科问题的可持续材料受到了广泛关注。MXenes作为一类新型二维材料出现，与亲水性物质相互作用时会产生金属导电性，其分层可得到厚度约为1纳米、边长在微米范围内的单层纳米片。分层后的MXene具有高长径比，使其成为多功能聚合物纳米复合材料诱人的纳米填料。在此，我们分类并讨论了主要基于多糖的电活性水凝胶（透明质酸（HA）、海藻酸钠（SA）、壳聚糖（CS）和纤维素）在生物医学应用中的结构、性质和应用，首先简要介绍了MXene的发展历程，随后依次讨论了包含多糖和MXenes的纳米复合材料的合成方法、结构和性质，包括它们的生物医学应用、细胞毒性和生物相容性方面。最后，对MXenes及其在生物医学领域的应用进行了探讨，着眼于未来预期的潜在机遇和挑战，从而推动它们的多方面应用。
