Rahman Zebunnessa, Murray Nicholas W G, Sala-Padró Jacint, Bartley Melissa, Dexter Mark, Fung Victor S C, Mahant Neil, Bleasel Andrew Fabian, Wong Chong H
Department of Neurology, Westmead Hospital, Sydney, NSW, Australia.
Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.
Front Hum Neurosci. 2022 Feb 24;16:815749. doi: 10.3389/fnhum.2022.815749. eCollection 2022.
To prospectively study the cingulate cortex for the localization and role of the grasping action in humans during electrical stimulation of depth electrodes.
All the patients ( = 23) with intractable focal epilepsy and a depth electrode stereotactically placed in the cingulate cortex, as part of their pre-surgical epilepsy evaluation from 2015 to 2017, were included. Cortical stimulation was performed and examined for grasping actions. Post-implantation volumetric T1 MRIs were co-registered to determine the exact electrode position.
Five patients (male: female 4:1; median age 31) exhibited contralateral grasping actions during electrical stimulation. All patients had electrodes implanted in the ventral bank of the right cingulate sulcus adjacent to the vertical anterior commissure (VAC) line. Stimulation of other electrodes in adjacent regions did not elicit grasping.
Grasping action elicited from a localized region in the mid-cingulate cortex (MCC) directly supports the concept of the cingulate cortex being crucially involved in the grasping network. This opens an opportunity to explore this region with deep brain stimulation as a motor neuromodulation target for treatment in specific movement disorders or neurorehabilitation.
前瞻性研究扣带回皮质在深度电极电刺激期间人类抓握动作的定位及作用。
纳入2015年至2017年作为术前癫痫评估一部分、患有难治性局灶性癫痫且深度电极立体定向植入扣带回皮质的所有患者（n = 23）。进行皮质刺激并检查抓握动作。将植入后容积T1磁共振成像进行配准以确定电极的确切位置。
5例患者（男性∶女性为4∶1；中位年龄31岁）在电刺激期间出现对侧抓握动作。所有患者的电极均植入右侧扣带沟腹侧紧邻垂直前连合（VAC）线处。刺激相邻区域的其他电极未引发抓握动作。
从扣带回中部皮质（MCC）的局部区域引发的抓握动作直接支持扣带回皮质关键参与抓握网络这一概念。这为通过深部脑刺激探索该区域作为特定运动障碍或神经康复治疗的运动神经调节靶点提供了契机。
