School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Tianjin University and Health-Biotech United Group Joint Laboratory of Innovative Drug Development and Translational Medicine, Tianjin University, Tianjin, China.
Front Immunol. 2022 Feb 25;13:811122. doi: 10.3389/fimmu.2022.811122. eCollection 2022.
The type-I interferon (IFN-I) signaling pathway plays pivot roles in defending against pathogen invasion. Exogenous ssRNA and dsRNA could be immunogenic. RNA-mediated IFN signaling is extensively studied in the field. The incorrect functioning of this pathway leads to either autoimmune diseases or suffering from microorganism invasion. From the discrimination of "self" and "non-self" molecules by receptors to the fine-tune modulations in downstream cascades, all steps are under the surveillance featured by complex feedbacks and regulators. Studies in recent years highlighted the emerging roles of long noncoding RNAs (lncRNAs) as a reservoir for signaling regulation. LncRNAs bind to targets through the structure and sequence, and thus the mechanisms of action can be complex and specific. Here, we summarized lncRNAs modulating the RNA-activated IFN-I signaling pathway according to the event order during the signaling. We hope this review help understand how lncRNAs are participating in the regulation of IFN-I signaling.
I 型干扰素 (IFN-I) 信号通路在抵御病原体入侵方面发挥着关键作用。外源性 ssRNA 和 dsRNA 可能具有免疫原性。RNA 介导的 IFN 信号转导在该领域得到了广泛研究。该途径的错误功能导致自身免疫性疾病或微生物入侵。从受体对“自我”和“非自我”分子的区分，到下游级联反应的精细调控，所有步骤都受到复杂反馈和调节剂的监控。近年来的研究强调了长非编码 RNA (lncRNA) 作为信号调控库的新兴作用。lncRNA 通过结构和序列与靶标结合，因此作用机制可能复杂而具体。在这里，我们根据信号转导过程中的事件顺序，总结了调节 RNA 激活的 IFN-I 信号通路的 lncRNA。我们希望这篇综述有助于理解 lncRNA 如何参与 IFN-I 信号转导的调控。
