Sani D, Abdu P A, Mamman M, Jolayemi K O
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Nigeria.
Clinical Pharmacology Specialty, Medicine Faculty, Ahmadu Bello University Study Center, College of Veterinary Surgeons, Nigeria.
Toxicol Rep. 2022 Mar 1;9:293-297. doi: 10.1016/j.toxrep.2022.02.010. eCollection 2022.
Povidone-iodine (Polidine®) is a synthetic broad-spectrum antiseptic being applied topically to treat wounds and prevent their infection. It has been however reported with the assertions that it is effective in the treatment of infectious bursa disease (IBD) when administered orally by practicing Veterinarians and other poultry handlers. Acute kidney injury has been reported also with povidone iodine ingestion. Hence, in this study, graded dose administration was conducted to ascertain its safety profile. Forty chicks were obtained from a poultry hatchery in Ibadan, Oyo State. They were randomly divided into four (4) groups of ten chicks each. Group I served as negative control, groups II, III and IV were administered Polidine® at 1 mL/50 L, 1 mL/25 L, and 1 mL/10 L of water respectively for 7 days. Blood samples were collected on Days 3 and 7 post administration for determination of haematological and biochemical parameters. Liver and Kidney tissues were harvested following termination of the experiment and processed for histopathological examination. Results revealed no significant (p > 0.05) effect in the haematological and biochemical parameters of cockerels treated with Povidone iodine at 1 mL/50 and 25 L of water. On histopathological examination no lesion was also observed in the liver and kidney tissues of groups I, II and III (normal control, 1 mL/50 and 25 L respectively) when compared to group IV (1 mL PI /50 L of water) where lesions were recorded. Hence, this study has shown the relative safety of povidone iodine at different doses in cockerels.
聚维酮碘（碘伏®）是一种合成的广谱抗菌剂，用于局部治疗伤口并预防感染。然而，有兽医和其他家禽饲养者称，口服聚维酮碘对治疗传染性法氏囊病（IBD）有效。也有报告称，摄入聚维酮碘会导致急性肾损伤。因此，在本研究中，进行了分级剂量给药以确定其安全性。从奥约州伊巴丹的一家家禽孵化场获得40只雏鸡。它们被随机分为4组，每组10只。第一组作为阴性对照，第二组、第三组和第四组分别以1 mL/50 L、1 mL/25 L和1 mL/10 L的比例将碘伏®加入水中，给药7天。在给药后的第3天和第7天采集血样，以测定血液学和生化参数。实验结束后，采集肝脏和肾脏组织，进行组织病理学检查。结果显示，以1 mL/50 L和1 mL/25 L的比例将聚维酮碘加入水中处理的公鸡，其血液学和生化参数没有显著影响（p > 0.05）。组织病理学检查发现，与记录到损伤的第四组（1 mL聚维酮碘/10 L水）相比，第一组、第二组和第三组（分别为正常对照、1 mL/50 L和1 mL/25 L）的肝脏和肾脏组织没有损伤。因此，本研究表明了不同剂量的聚维酮碘在公鸡中的相对安全性。
