瓦德迈达尼隔离中心新冠肺炎患者严重疾病进展的临床特征及相关危险因素：一项多中心回顾性横断面研究
Clinical Characteristics and Risk Factors Associated with Severe Disease Progression among COVID-19 Patients In Wad Medani Isolation Centers: A Multicenter Retrospective Cross-Sectional Study.
作者信息
Yousif Mohammed Yousif Elnaeem, Eljack Mohammed Mahmmoud Fadel Allah, Haroun Mazin S, Abbasher Hussien Mohamed Ahmed Khabab, Amir Osman, Alfatih Mohammed, Al Shiekh Akram Khalid Al Tigany, Ahmed Mazin Abdelraham Osman, Nour Alshareef, Alhusseini Radi Tofaha, Osman Waddah Aljaely Mohammed, Abdulkarim Mohamed, Omer Mohammed Eltahier Abdalla, Mahgoub Ibrahim M
机构信息
Faculty of Medicine University of Gezira Wad Madani Sudan.
Medani Heart Diseases and Surgery Center University of Bakht Alruda Ed Dueim Sudan.
出版信息
Health Sci Rep. 2022 Feb 28;5(2):e523. doi: 10.1002/hsr2.523. eCollection 2022 Mar.
BACKGROUND
Since December 2019, (COVID-19) has had a significant impact on global health systems. Because little is known about the clinical characteristics and risk factors connected with COVID-19 severity in Sudanese patients, it is vital to summarize the clinical characteristics of COVID-19 patients and to investigate the risk factors linked to COVID-19 severity.
OBJECTIVES
We aimed to assess the clinical characteristics of COVID-19 patients and look into risk factors associated with COVID-19 severity.
METHODS
This is a retrospective cross-sectional study that took place in two Isolation Centers in Wad Medani, Gezira State, Sudan. Four hundred and eighteen patients were included between May 2020 and May 2021. All COVID-19 patients over the age of 18 who were proven COVID-19 positive by nucleic acid testing or had characteristics suggestive of COVID-19 on a chest CT scan and had a complete medical record in the study period were included.
RESULTS
The participants in this study were 418 confirmed COVID-19 cases with a median age of 66.313 years. There were 279 men (66.7%) among the patients. The most prevalent comorbidities were hypertension (n = 195; 46.7%) and diabetes (n = 187; 44.7%). Fever (n = 303; 72.5%), cough (n = 278; 66.5%), and dyspnea (n = 256; 61.2%) were the most prevalent symptoms at the onset of COVID-19. The overall mortality rate (n = 148) was 35.4%. Patients with severe illness had a mortality rate of 42.3% (n = 118). Older age, anemia, neutrophilia, and lymphocytopenia, as well as higher glucose, HbA1c, and creatinine levels, were all linked to severe COVID-19, according to the chi-square test and analysis of variance analysis.
CONCLUSION
Sixteen variables were found to be associated with COVID-19 severity. These patients are more prone to go through a serious infection and as a result have a greater death rate than those who do not have these characteristics.
背景
自2019年12月以来，新型冠状病毒肺炎（COVID-19）对全球卫生系统产生了重大影响。由于对苏丹患者中与COVID-19严重程度相关的临床特征和危险因素了解甚少，总结COVID-19患者的临床特征并调查与COVID-19严重程度相关的危险因素至关重要。
目的
我们旨在评估COVID-19患者的临床特征，并探究与COVID-19严重程度相关的危险因素。
方法
这是一项回顾性横断面研究，在苏丹杰济拉州瓦德迈达尼的两个隔离中心进行。2020年5月至2021年5月期间纳入了418名患者。所有年龄在18岁以上、经核酸检测确诊为COVID-19阳性或胸部CT扫描具有COVID-19特征且在研究期间有完整病历的COVID-19患者均被纳入。
结果
本研究的参与者为418例确诊的COVID-19病例，中位年龄为66.313岁。患者中有279名男性（66.7%）。最常见的合并症是高血压（n = 195；46.7%）和糖尿病（n = 187；44.7%）。发热（n = 303；72.5%）、咳嗽（n = 278；66.5%）和呼吸困难（n = 256；61.2%）是COVID-19发病时最常见的症状。总死亡率（n = 148）为35.4%。重症患者的死亡率为42.3%（n = 118）。根据卡方检验和方差分析，年龄较大、贫血、中性粒细胞增多、淋巴细胞减少以及较高的血糖、糖化血红蛋白和肌酐水平均与重症COVID-19相关。
结论
发现16个变量与COVID-19严重程度相关。这些患者比没有这些特征的患者更容易发生严重感染，因此死亡率更高。
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