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Bone Bricks: The Effect of Architecture and Material Composition on the Mechanical and Biological Performance of Bone Scaffolds.

作者信息

Daskalakis Evangelos, Huang Boyang, Vyas Cian, Acar Anil A, Liu Fengyuan, Fallah Ali, Cooper Glen, Weightman Andrew, Blunn Gordon, Koç Bahattin, Bartolo Paulo

机构信息

School of Mechanical, Aerospace and Civil Engineering, University of Manchester, ManchesterM13 9PL, U.K.

Integrated Manufacturing Technologies Research and Application Center, Sabanci University, Tuzla 34956, Istanbul, Turkey.

出版信息

ACS Omega. 2022 Feb 22;7(9):7515-7530. doi: 10.1021/acsomega.1c05437. eCollection 2022 Mar 8.

DOI:10.1021/acsomega.1c05437
PMID:35284712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8908495/
Abstract

Large bone loss injuries require high-performance scaffolds with an architecture and material composition resembling native bone. However, most bone scaffold studies focus on three-dimensional (3D) structures with simple rectangular or circular geometries and uniform pores, not able to recapitulate the geometric characteristics of the native tissue. This paper addresses this limitation by proposing novel anatomically designed scaffolds (bone bricks) with nonuniform pore dimensions (pore size gradients) designed based on new lay-dawn pattern strategies. The gradient design allows one to tailor the properties of the bricks and together with the incorporation of ceramic materials allows one to obtain structures with high mechanical properties (higher than reported in the literature for the same material composition) and improved biological characteristics.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/0ff8a00e4d07/ao1c05437_0020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/e52f76a7c474/ao1c05437_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/b664b7c29f1b/ao1c05437_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/6869fcf354eb/ao1c05437_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/a3799de61883/ao1c05437_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/fffbe3fe406e/ao1c05437_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/b1581f81c95f/ao1c05437_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/8e390afbea98/ao1c05437_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/094afbff5d50/ao1c05437_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/296ba9c2759f/ao1c05437_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/e4faed01dba8/ao1c05437_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/0932a0a89247/ao1c05437_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/5c774751c725/ao1c05437_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/5bb46fb81aad/ao1c05437_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/383e41d49ef3/ao1c05437_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/2e1a79a5ad25/ao1c05437_0016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/71ca18f8c869/ao1c05437_0017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/3a6281424063/ao1c05437_0018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/5c1dacadbd49/ao1c05437_0019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/0ff8a00e4d07/ao1c05437_0020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/e52f76a7c474/ao1c05437_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/b664b7c29f1b/ao1c05437_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/6869fcf354eb/ao1c05437_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/a3799de61883/ao1c05437_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/fffbe3fe406e/ao1c05437_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/b1581f81c95f/ao1c05437_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/8e390afbea98/ao1c05437_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/094afbff5d50/ao1c05437_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/296ba9c2759f/ao1c05437_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/e4faed01dba8/ao1c05437_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/0932a0a89247/ao1c05437_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/5c774751c725/ao1c05437_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/5bb46fb81aad/ao1c05437_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/383e41d49ef3/ao1c05437_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/2e1a79a5ad25/ao1c05437_0016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/71ca18f8c869/ao1c05437_0017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/3a6281424063/ao1c05437_0018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/5c1dacadbd49/ao1c05437_0019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbe5/8908495/0ff8a00e4d07/ao1c05437_0020.jpg

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本文引用的文献

[1]
Effects of surface area and topography on 3D printed tricalcium phosphate scaffolds for bone grafting applications.

Addit Manuf. 2021-3

[2]
Capitate shortening osteotomy with or without vascularized bone grafting for the treatment of early stages of Kienböck's disease.

Int Orthop. 2021-10

[3]
A self-powered implantable and bioresorbable electrostimulation device for biofeedback bone fracture healing.

Proc Natl Acad Sci U S A. 2021-7-13

[4]
Refracture after Ilizarov fixation of infected ununited tibial fractures-an analysis of eight hundred and twelve cases.

Int Orthop. 2021-8

[5]
Investigating the Influence of Architecture and Material Composition of 3D Printed Anatomical Design Scaffolds for Large Bone Defects.

Int J Bioprint. 2021-2-24

[6]
Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering.

Nanomaterials (Basel). 2021-4-6

[7]
Alternative Use of the Ilizarov Apparatus Set in Case of Complications During Intramedullary Nail Removal: A Case Report.

JBJS Case Connect. 2021-4-20

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Megaprosthesis Versus Allograft Prosthesis Composite for the Management of Massive Skeletal Defects: A Meta-Analysis of Comparative Studies.

Curr Rev Musculoskelet Med. 2021-6

[9]
Antibacterial biomaterials in bone tissue engineering.

J Mater Chem B. 2021-3-21

[10]
Radial shortening, bone grafting and vascular pedicle implantation versus radial shortening alone in Kienböck's disease.

J Hand Surg Eur Vol. 2021-6

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