Wu-Chuang Alejandra, Hodžić Adnan, Mateos-Hernández Lourdes, Estrada-Peña Agustín, Obregon Dasiel, Cabezas-Cruz Alejandro
Anses, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, F-94700, France.
Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210, Vienna, Austria.
Curr Res Parasitol Vector Borne Dis. 2021 Jun 6;1:100036. doi: 10.1016/j.crpvbd.2021.100036. eCollection 2021.
The main importance of ticks resides in their ability to harbor pathogens that can be transmitted to terrestrial vertebrates including humans. Recently, studies have focused on the taxonomic and functional composition of the tick microbiome, its microbial diversity and variation under different factors including tick species, sex, and environment among others. Of special interest are the interactions between the tick, the microbiome and pathogens since tick microbiome can influence pathogen colonization within the tick vector, and potentially, transmission to the vertebrate host. In this review, we tackled a synthesis on the growing field of tick microbiomes. We focus on the current state of tick microbiome research, addressing controversial and hotly debated topics and advances in the precise manipulation of tick microbiome. Furthermore, we discuss the innovative anti-tick microbiota vaccines as a possible tool for microbiome modulation and thus, control of tick-borne diseases. Deciphering tick-microbiome pathogen interactions can spur new strategies to control tick-borne diseases modulation of tick microbiome.
蜱虫的主要重要性在于它们能够携带可传播给包括人类在内的陆生脊椎动物的病原体。最近，研究集中在蜱虫微生物组的分类和功能组成、其微生物多样性以及在不同因素（包括蜱虫种类、性别和环境等）下的变化。特别令人感兴趣的是蜱虫、微生物组和病原体之间的相互作用，因为蜱虫微生物组会影响病原体在蜱虫载体中的定殖，并可能影响其向脊椎动物宿主的传播。在这篇综述中，我们对蜱虫微生物组这一不断发展的领域进行了综合阐述。我们关注蜱虫微生物组研究的现状，探讨有争议和激烈辩论的话题以及蜱虫微生物组精确操控方面的进展。此外，我们讨论了创新的抗蜱虫微生物群疫苗，它可能是调节微生物组从而控制蜱传疾病的一种工具。解读蜱虫-微生物组-病原体之间的相互作用能够催生出控制蜱传疾病的新策略——调节蜱虫微生物组。
