Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium; Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.
Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium.
Carbohydr Polym. 2022 May 15;284:119152. doi: 10.1016/j.carbpol.2022.119152. Epub 2022 Jan 21.
Fungal exopolysaccharides (EPSs) are natural biopolymers with diverse potential applications in the biomedical, packaging, cosmetic, and food industries. Fungal EPSs are easy to extract and purify polysaccharides that are biodegradable, biocompatible, with low immunogenicity, bioadhesion ability, antibacterial activity, and contain different reactive groups such as hydroxyl, carboxyl, and amine for chemical modifications. Despite fast progress in identifying and characterization fungal EPSs for biomedical applications, i.e., wound healing, drug, and gene delivery, only a few products have been commercialized based on fungal EPSs. This review critically discusses potential biomedical applications of fungi sourced EPSs in tissue engineering (TE), drug and gene delivery.
真菌胞外多糖（EPSs）是具有多种潜在应用的天然生物聚合物，可应用于生物医学、包装、化妆品和食品行业。真菌 EPSs 易于提取和纯化多糖，这些多糖可生物降解、生物相容、免疫原性低、具有生物黏附能力、具有抗菌活性，并且含有不同的反应基团，如羟基、羧基和胺基，可进行化学修饰。尽管在鉴定和表征用于生物医学应用（例如伤口愈合、药物和基因传递）的真菌 EPSs 方面取得了快速进展，但基于真菌 EPSs 的商业化产品却寥寥无几。本综述批判性地讨论了真菌来源的 EPSs 在组织工程（TE）、药物和基因传递方面的潜在生物医学应用。
