Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Center of Biomedical Data Science, Yonsei University Wonju College of Medicine Wonju, Republic of Korea.
PLoS One. 2022 Mar 15;17(3):e0262526. doi: 10.1371/journal.pone.0262526. eCollection 2022.
Metabolic syndrome (MetS) is caused by both genetic and environmental factors, such as daily calorie intake, smoking, and alcohol consumption. Lifestyle factors, such as alcohol consumption, are considered to be related to the prevalence of MetS and plays an essential role in the pathogenesis and prognosis of depression.
We investigated the bidirectional association between lifestyle factors and MetS among Korean adults with depressive symptoms in third wave of a community-based cohort study. A total of 1,578 individuals, aged 39-72 years, who had MetS at baseline were recruited. Participants were divided into two groups according to depressive symptoms. Logistic regression models were used to estimate the risk of MetS.
The percentage of heavy drinkers was lower in men with depressive symptoms compared to those who did not (7.0% vs. 7.1%), while the percentage of current smokers were higher in participants who had depressive symptoms (40.2% vs. 30.0%). After adjusting for age, education, monthly income, body mass index (BMI), sleep duration, and volume of drinking and smoking status, logistic regression analysis demonstrated that male heavy drinkers with depressive symptoms were 2.75 times more likely to have MetS than those without depressive symptom. Conversely, depressive women with a high BMI were 3.70 times more likely to have MetS than in those with lower BMI. Limitations The cross-sectional nature of the study, and the study population ethnicity and ages were limitations.
Lifestyle factors, such as alcohol consumption, may be associated with the risk of MetS in adults with depressive symptoms.
代谢综合征（MetS）是由遗传和环境因素共同引起的，如每日热量摄入、吸烟和饮酒等。生活方式因素，如饮酒，被认为与 MetS 的患病率有关，并在抑郁症的发病机制和预后中发挥重要作用。
我们在一项基于社区的队列研究的第三波中，调查了生活方式因素与韩国有抑郁症状的成年人代谢综合征之间的双向关联。共招募了 1578 名基线时患有代谢综合征的 39-72 岁成年人。参与者根据抑郁症状分为两组。使用逻辑回归模型估计代谢综合征的风险。
与没有抑郁症状的人相比，有抑郁症状的男性中大量饮酒者的比例较低（7.0%比 7.1%），而有抑郁症状的参与者中目前吸烟者的比例较高（40.2%比 30.0%）。在调整年龄、教育、月收入、体重指数（BMI）、睡眠时间以及饮酒和吸烟状况的体积后，逻辑回归分析表明，有抑郁症状的男性大量饮酒者发生代谢综合征的风险是没有抑郁症状者的 2.75 倍。相反，BMI 较高的抑郁女性发生代谢综合征的风险是 BMI 较低者的 3.70 倍。局限性 本研究为横断面研究，且研究人群的种族和年龄存在局限性。
生活方式因素，如饮酒，可能与有抑郁症状的成年人代谢综合征的风险相关。
