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油和吐温浓度对经乳化海藻糖-6,6'-二霉菌酸酯（索状因子）预处理的小鼠内毒素致死性增强的影响。

Influence of oil and Tween concentrations on enhanced endotoxin lethality in mice pretreated with emulsified trehalose-6,6'-dimycolate (cord factor).

作者信息

Yarkoni E, Rapp H J

出版信息

Infect Immun. 1979 May;24(2):571-2. doi: 10.1128/iai.24.2.571-572.1979.

DOI:10.1128/iai.24.2.571-572.1979
PMID:378860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414340/
Abstract

Susceptibility to the lethal toxicity of endotoxin in mice pretreated with emulsified trehalose-6,6'-dimycolate was enhanced by (i) increasing the oil concentration while keeping the Tween concentration constant; and (ii) decreasing the Tween concentration, while keeping the oil concentration constant.

摘要

在用乳化海藻糖-6,6'-二霉菌酸酯预处理的小鼠中，内毒素致死毒性的易感性通过以下方式增强：（i）在保持吐温浓度恒定的同时增加油浓度；以及（ii）在保持油浓度恒定的同时降低吐温浓度。

相似文献

1
Influence of oil and Tween concentrations on enhanced endotoxin lethality in mice pretreated with emulsified trehalose-6,6'-dimycolate (cord factor).油和吐温浓度对经乳化海藻糖-6,6'-二霉菌酸酯（索状因子）预处理的小鼠内毒素致死性增强的影响。
Infect Immun. 1979 May;24(2):571-2. doi: 10.1128/iai.24.2.571-572.1979.
2
Failure of trehalose-6,6'-dimycolate (P3 or cord factor) to enhance endotoxin lethality in mice.海藻糖-6,6'-二霉菌酸酯（P3或索状因子）未能增强内毒素对小鼠的致死性。
Infect Immun. 1976 Dec;14(6):1375-7. doi: 10.1128/iai.14.6.1375-1377.1976.
3
Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs.油的类型和表面活性剂浓度对乳化的牛分枝杆菌卡介苗细胞壁诱导豚鼠肿瘤消退功效的影响。
Infect Immun. 1980 Jun;28(3):881-6. doi: 10.1128/iai.28.3.881-886.1980.
4
Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.
Int J Cancer. 1977 Jun 15;19(6):818-21. doi: 10.1002/ijc.2910190612.
5
Stimulation of macrophages by cord factor and by heat-killed and living BCG.用索状因子以及热灭活和活卡介苗刺激巨噬细胞。
Infect Immun. 1977 Apr;16(1):1-8. doi: 10.1128/iai.16.1.1-8.1977.
6
Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets.静脉注射乳化海藻糖-6,6'-二甲酰基海藻糖（索状因子）后小鼠肺部肉芽肿的形成：反应强度取决于油滴的大小分布。
Infect Immun. 1977 Nov;18(2):552-4. doi: 10.1128/iai.18.2.552-554.1977.
7
Toxicity of emulsified trehalose-6,6'-dimycolate (cord factor) in mice depends on size distribution of mineral oil droplets.乳化海藻糖-6,6'-二霉菌酸酯（索状因子）对小鼠的毒性取决于矿物油滴的大小分布。
Infect Immun. 1978 Jun;20(3):856-60. doi: 10.1128/iai.20.3.856-860.1978.
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Influence of surfactant concentration on the antitumor activity of emulsified components of mycobacteria.
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Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil.在病灶内注射用2,6,10,15,19,23-六甲基-2,6,10,14,18,22-二十四碳六烯（角鲨烯）、2,6,10,15,19,23-六甲基二十四烷（角鲨烷）、花生油或矿物油乳化的分枝杆菌成分后肿瘤消退情况。
Cancer Res. 1979 May;39(5):1518-20.
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Biomedical applications of chromatographic fraction containing trehalose dimycolate in squalane emulsion.含有海藻糖二霉菌酸酯的色谱馏分在角鲨烷乳剂中的生物医学应用。
J Chromatogr. 1988 May 25;440:473-8. doi: 10.1016/s0021-9673(00)94552-7.

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Front Immunol. 2017 Dec 20;8:1836. doi: 10.3389/fimmu.2017.01836. eCollection 2017.
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Development of a trehalose 6,6'-dimycolate model which explains cord formation by Mycobacterium tuberculosis.海藻糖6,6'-二霉菌酸酯模型的开发，该模型解释了结核分枝杆菌的索状形成。
Infect Immun. 1993 Jun;61(6):2296-303. doi: 10.1128/iai.61.6.2296-2303.1993.

本文引用的文献

1
Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions.感染分枝杆菌的小鼠对内毒素的高反应性。反应的诱导与激发。
Immunology. 1961 Oct;4(4):354-65.
2
Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets.静脉注射乳化海藻糖-6,6'-二甲酰基海藻糖（索状因子）后小鼠肺部肉芽肿的形成：反应强度取决于油滴的大小分布。
Infect Immun. 1977 Nov;18(2):552-4. doi: 10.1128/iai.18.2.552-554.1977.
3
Failure of trehalose-6,6'-dimycolate (P3 or cord factor) to enhance endotoxin lethality in mice.海藻糖-6,6'-二霉菌酸酯（P3或索状因子）未能增强内毒素对小鼠的致死性。
Infect Immun. 1976 Dec;14(6):1375-7. doi: 10.1128/iai.14.6.1375-1377.1976.
4
Immunotherapy with an intralesionally administered synthetic cord factor analogue.
Int J Cancer. 1978 Nov 15;22(5):564-9. doi: 10.1002/ijc.2910220510.
5
Toxicity of emulsified trehalose-6,6'-dimycolate (cord factor) in mice depends on size distribution of mineral oil droplets.乳化海藻糖-6,6'-二霉菌酸酯（索状因子）对小鼠的毒性取决于矿物油滴的大小分布。
Infect Immun. 1978 Jun;20(3):856-60. doi: 10.1128/iai.20.3.856-860.1978.
6
Enhancement of nonspecific immunity to bacterial infection by cord factor (6,6'-trehalose dimycolate).海藻糖二霉菌酸酯（索状因子）对细菌感染非特异性免疫力的增强作用。
J Infect Dis. 1977 May;135(5):771-7. doi: 10.1093/infdis/135.5.771.
7
Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.在瘤内注射内毒素和分枝杆菌硫脂的乳化混合物后，移植的豚鼠肝癌发生消退。
Infect Immun. 1979 May;24(2):357-62. doi: 10.1128/iai.24.2.357-362.1979.
8
Nonspecific immunostimulant activities of synthetic trehalose-6,6'-diesters (lower homologs of cord factor).合成海藻糖-6,6'-二酯（类脂酸的低级同系物）的非特异性免疫刺激活性。
Infect Immun. 1978 Apr;20(1):12-9. doi: 10.1128/iai.20.1.12-19.1978.
9
Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.
Int J Cancer. 1977 Jun 15;19(6):818-21. doi: 10.1002/ijc.2910190612.