Carta Mauro Giovanni, Fornaro Michele, Minerba Luigi, Pau Massimiliano, Velluzzi Fernanda, Atzori Laura, Aviles Gonzalez Cesar Ivan, Romano Ferdinando, Littera Roberto, Chessa Luchino, Firinu Davide, Del Giacco Stefano, Restivo Angelo, Deidda Simona, Orrù Germano, Scano Alessandra, Onali Simona, Coghe Ferdinando, Kalcev Goce, Cossu Giulia
Department of Medical Science and Public Health, University of Cagliari.
Department of Psychiatry, Federico II University of Naples.
J Public Health Res. 2022 Mar 16;11(2):2768. doi: 10.4081/jphr.2022.2768.
Functioning of Social Behavioral Rhythms (SBRs) may affect resilience toward stressful events across different age groups. However, the impact of SBRs on the coronavirus disease of 2019 (COVID-19) in elder people is yet to ascertain, representing the aim of the present report.
Follow-up of a peer-reviewed randomized controlled trial on exercise on old adults (³65 years), concurrent to the onset of the pandemic-related lockdown. Post-RCT evaluations occurred after further 12 and 36 weeks since the beginning of the lockdown phase. People with Major Depressive Episode (MDE) at week-48 (follow-up endpoint) were deemed as cases, people without such condition were considered controls. MDE was ascertained using the Patient Health Questionnaire-9 (PHQ-9); SBRs functioning at week 12 onward, through the Brief Symptom Rating Scale (BSRS).
Seventy-nine individuals (53.2%, females) entered the RCT-follow-up phase. The frequency of MDE did not significantly change before versus during lockdown (OR 2.60, CI95%=0.87-9.13). People with BSRS>1 standard deviation of the whole sample score at week-12 had an inflated risk of DE during lockdown (OR=5.6, 95%CI: 1.5-21.4) compared to those with lower BSRS scores. Such odd hold after excluding individuals with MDD at week-12. The post-hoc analysis could be potentially affected by selection bias.
Overall, older adults were resilient during the first phase of the pandemic when functioning of pre-lockdown was still preserved, in contrast to the subsequent evaluations when the impairment of daily rhythms was associated with impaired reliance.
社会行为节律（SBRs）的功能可能会影响不同年龄组对压力事件的恢复力。然而，SBRs对老年人2019冠状病毒病（COVID-19）的影响尚待确定，这也是本报告的目的。
在与大流行相关的封锁开始时，对一项关于老年人（≥65岁）运动的同行评审随机对照试验进行随访。随机对照试验后的评估在封锁阶段开始后的12周和36周进行。在第48周（随访终点）患有重度抑郁发作（MDE）的人被视为病例，没有这种情况的人被视为对照。使用患者健康问卷-9（PHQ-9）确定MDE；从第12周起，通过简明症状评定量表（BSRS）评估SBRs功能。
79人（53.2%为女性）进入随机对照试验随访阶段。封锁前与封锁期间MDE的发生率没有显著变化（比值比2.60，95%置信区间=0.87-9.13）。与BSRS得分较低的人相比，在第12周时BSRS高于整个样本得分1个标准差的人在封锁期间发生MDE的风险更高（比值比=5.6，95%置信区间：1.5-21.4）。在排除第12周患有重度抑郁症的个体后，这种差异仍然存在。事后分析可能受到选择偏倚的影响。
总体而言，在大流行的第一阶段，当封锁前的功能仍得以保留时，老年人具有恢复力，而在随后的评估中，日常节律的受损与恢复力受损相关。
