英国生物银行中包含103200个样本的加速计数据集揭示了人类睡眠表型的全貌。
The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes.
作者信息
Katori Machiko, Shi Shoi, Ode Koji L, Tomita Yasuhiro, Ueda Hiroki R
机构信息
Department of Information Physics and Computing, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo 113-0033, Japan.
Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
出版信息
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2116729119. doi: 10.1073/pnas.2116729119. Epub 2022 Mar 18.
SignificanceHuman sleep phenotypes are diversified by genetic and environmental factors, and a quantitative classification of sleep phenotypes would lead to the advancement of biomedical mechanisms underlying human sleep diversity. To achieve that, a pipeline of data analysis, including a state-of-the-art sleep/wake classification algorithm, the uniform manifold approximation and projection (UMAP) dimension reduction method, and the density-based spatial clustering of applications with noise (DBSCAN) clustering method, was applied to the 100,000-arm acceleration dataset. This revealed 16 clusters, including seven different insomnia-like phenotypes. This kind of quantitative pipeline of sleep analysis is expected to promote data-based diagnosis of sleep disorders and psychiatric disorders that tend to be complicated by sleep disorders.
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