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大规模快速新冠病毒检测能替代封锁吗?

Is large-scale rapid CoV-2 testing a substitute for lockdowns?

机构信息

Johannes Gutenberg University Mainz, Mainz, Germany.

University of Hamburg, Hamburg, Germany.

出版信息

PLoS One. 2022 Mar 18;17(3):e0265207. doi: 10.1371/journal.pone.0265207. eCollection 2022.

Abstract

BACKGROUND

Various forms of contact restrictions have been adopted in response to the Covid-19 pandemic. Around February 2021, rapid testing appeared as a new policy instrument. Some claim it may serve as a substitute for contact restrictions. We study the strength of this argument by evaluating the effects of a unique policy experiment: In March and April 2021, the city of Tübingen set up a testing scheme while relaxing contact restrictions.

METHODS

We compare case rates in Tübingen county to an appropriately identified control unit. We employ the synthetic control method. We base interpretations of our findings on an extended SEIR model.

FINDINGS

The experiment led to an increase in the reported case rate. This increase is robust across alternative statistical specifications. This is also due to more testing leading initially to more reported cases. An epidemiological model that corrects for 'more cases due to more testing' and 'reduced testing and reporting during the Easter holiday' confirms that the overall effect of the experiment led to more infections.

INTERPRETATION

The number of rapid tests were not sufficiently high in this experiment to compensate for more contacts and thereby infections caused by relaxing contact restrictions.

摘要

背景

为应对新冠疫情,各国采取了各种形式的接触限制措施。大约在 2021 年 2 月,快速检测成为一种新的政策工具。有人声称,它可能成为接触限制措施的替代品。我们通过评估一项独特的政策实验的效果来研究这一观点的说服力:2021 年 3 月至 4 月,蒂宾根市在放宽接触限制的同时制定了一项检测计划。

方法

我们将图宾根县的病例率与一个适当确定的对照组进行比较。我们采用合成控制法。我们基于扩展的 SEIR 模型对研究结果进行解释。

结果

该实验导致报告的病例率增加。这一结果在替代的统计规范下仍然稳健。这也是由于最初更多的检测导致更多的报告病例。一个纠正“因检测更多而导致更多病例”和“复活节假期期间检测和报告减少”的流行病学模型证实,实验的总体效果导致了更多的感染。

解释

在这项实验中,快速检测的数量不够高,无法弥补放宽接触限制所导致的更多接触和感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fb/8932588/68976b0d053b/pone.0265207.g001.jpg

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