Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos.
作者信息
Wei Yinghui, Li Zhifang, Xu Kui, Feng Hu, Xie Long, Li Di, Zuo Zhenrui, Zhang Meiling, Xu Chunlong, Yang Hui, Zuo Erwei
机构信息
Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.
Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
出版信息
Cell Discov. 2022 Mar 18;8(1):27. doi: 10.1038/s41421-022-00391-5.
Abstract
摘要
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