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Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos.

作者信息

Wei Yinghui, Li Zhifang, Xu Kui, Feng Hu, Xie Long, Li Di, Zuo Zhenrui, Zhang Meiling, Xu Chunlong, Yang Hui, Zuo Erwei

机构信息

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

出版信息

Cell Discov. 2022 Mar 18;8(1):27. doi: 10.1038/s41421-022-00391-5.

DOI:10.1038/s41421-022-00391-5
PMID:35304438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8933521/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f7/8933521/b8a1b061a352/41421_2022_391_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f7/8933521/b8a1b061a352/41421_2022_391_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f7/8933521/b8a1b061a352/41421_2022_391_Fig1_HTML.jpg

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Cell Discov. 2021 Oct 19;7(1):95. doi: 10.1038/s41421-021-00325-7.
2
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing.通过DdCBE介导的线粒体DNA碱基编辑在斑马鱼中对线粒体疾病进行精确建模。
Cell Discov. 2021 Sep 3;7(1):78. doi: 10.1038/s41421-021-00307-9.
3
Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases.利用 DddA-TALE 融合脱氨酶在小鼠中进行线粒体 DNA 编辑。
Mitochondrial Commun. 2025;3:26-43. doi: 10.1016/j.mitoco.2025.03.001. Epub 2025 Mar 26.
4
Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases.线粒体DNA编辑：治疗神经退行性疾病的关键。
Genes Dis. 2024 Sep 21;12(4):101437. doi: 10.1016/j.gendis.2024.101437. eCollection 2025 Jul.
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The Complexities of Interspecies Somatic Cell Nuclear Transfer: From Biological and Molecular Insights to Future Perspectives.种间体细胞核移植的复杂性：从生物学和分子学见解到未来展望
Int J Mol Sci. 2025 Apr 2;26(7):3310. doi: 10.3390/ijms26073310.
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Aging-associated accumulation of mitochondrial DNA mutations in tumor origin.衰老相关的线粒体DNA突变在肿瘤起源中的积累。
Life Med. 2022 Aug 17;1(2):149-167. doi: 10.1093/lifemedi/lnac014. eCollection 2022 Oct.
7
Mitochondrial base editing: from principle, optimization to application.线粒体碱基编辑：从原理、优化到应用
Cell Biosci. 2025 Jan 24;15(1):9. doi: 10.1186/s13578-025-01351-8.
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