Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia; Microbiology Unit, Department of Biological Sciences, College of Natural and Applied Sciences, Summit University Offa, Offa PMB 4412, Kwara, Nigeria.
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Acta Trop. 2022 Jul;231:106408. doi: 10.1016/j.actatropica.2022.106408. Epub 2022 Mar 16.
Dengue and chikungunya virus are important arboviruses of public health concern. In the past decades, they have accounted for numerous outbreaks of dengue and chikungunya in different parts of the world. Several cases of concurrent infection of dengue and chikungunya have been documented. However, the true burden of this concurrent infection is unknown. Here, a systematic review and meta-analysis of published data on the prevalence of dengue and chikungunya coinfection in the human population was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Six electronic databases (Web of science, Embase, PubMed, ScienceDirect, Scopus, and Google Scholar) were searched without year or language restrictions for relevant studies. The study protocol was registered with PROSPERO (CRD42020175344). Eighty-three studies involving a total of 43,341 participants were included. The random-effects model was employed to calculate the summary estimates. A pooled global prevalence of 2.5% (95% CI: 1.8-3.4) was obtained for dengue and chikungunya coinfection. Males and females appear to be coinfected at a fairly similar rate. Among the regions, Asia accounted for the highest prevalence (3.3%, 95% CI: 2.3-4.6) while North America was the least (0.8%, 95% CI: 0.3-2.4). The prevalence estimates varied across different countries. A much higher prevalence rates were obtained for Colombia (37.4%, 95% CI: 9.1-78.1), Madagascar (18.2%, 95% CI: 10.1-30.6), Laos (12.5%, 95% CI: 5.3-26.7), Maldives (4.5%, 95% CI: 1.5-13.0) and Thailand (3.7%, 95% CI: 0.4-26.3). This first extensive systematic review and meta-analysis reveals dengue and chikungunya coinfection as a global problem worthy of consideration. It is therefore pertinent that both infections be assessed during diagnosis, mosquito vector control practices be implemented, and vaccine development strides be supported globally.
登革热和基孔肯雅热病毒是重要的公共卫生关注的虫媒病毒。在过去几十年中，它们在世界不同地区造成了许多登革热和基孔肯雅热的爆发。已经记录了几例登革热和基孔肯雅热同时感染的病例。然而，这种同时感染的真实负担尚不清楚。在这里，根据系统评价和荟萃分析的首选报告项目，对已发表的人群中登革热和基孔肯雅热同时感染流行率的文献进行了系统评价和荟萃分析。没有时间和语言限制，在六个电子数据库（Web of Science、Embase、PubMed、ScienceDirect、Scopus 和 Google Scholar）中搜索了相关研究。研究方案在 PROSPERO（CRD42020175344）中进行了注册。共有 83 项研究涉及 43341 名参与者。采用随机效应模型计算汇总估计值。得出登革热和基孔肯雅热同时感染的全球患病率为 2.5%（95%CI：1.8-3.4）。男性和女性似乎以相当相似的速度同时感染。在各地区中，亚洲的患病率最高（3.3%，95%CI：2.3-4.6），而北美的患病率最低（0.8%，95%CI：0.3-2.4）。不同国家的患病率估计值有所不同。哥伦比亚（37.4%，95%CI：9.1-78.1）、马达加斯加（18.2%，95%CI：10.1-30.6）、老挝（12.5%，95%CI：5.3-26.7）、马尔代夫（4.5%，95%CI：1.5-13.0）和泰国（3.7%，95%CI：0.4-26.3）的患病率估计值较高。这是首次对登革热和基孔肯雅热同时感染进行的广泛系统评价和荟萃分析，揭示了这一同时感染是一个值得关注的全球性问题。因此，在诊断时应同时评估这两种感染，实施蚊虫媒介控制措施，并在全球范围内支持疫苗开发工作。
