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通过对木质组织进行非靶向代谢组学揭示与葡萄枝干病害和生物防治剂Vintec相关的病原体早期反应的改变

Modification of Early Response of to Pathogens Relating to Esca Disease and Biocontrol Agent Vintec Revealed By Untargeted Metabolomics on Woody Tissues.

作者信息

Chervin Justine, Romeo-Oliván Ana, Fournier Sylvie, Puech-Pages Virginie, Dumas Bernard, Jacques Alban, Marti Guillaume

机构信息

Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, Toulouse INP, Toulouse, France.

Metatoul-AgromiX Platform, LRSV, Université de Toulouse, CNRS, UPS, Toulouse INP, Toulouse, France.

出版信息

Front Microbiol. 2022 Mar 2;13:835463. doi: 10.3389/fmicb.2022.835463. eCollection 2022.

DOI:10.3389/fmicb.2022.835463
PMID:35308402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8924477/
Abstract

Esca disease is one of the most destructive grapevine trunk diseases. and are two of the known fungal pathogens associated with this disease. Today, biocontrol agents against Esca are mainly based on the use of the strain of the mycoparasite fungal genus such as the Vintec product. The aim of this study was to investigate early response of woody tissues to Esca pathogens and identify metabolites that could be correlated with a biocontrol activity within a complex woody matrix. An untargeted liquid chromatography-high-resolution mass spectrometry metabolomic approach coupled to a spectral similarity network was used to highlight clusters of compounds associated with the plant response to pathogens and biocontrol. Dereplication highlighted the possible role of glycerophospholipids and polyphenol compounds, the latest mainly belonging to stilbenoids. Antifungal activity of some relevant biomarkers, evaluated on and , suggests that some of these compounds can play a role to limit the development of Esca pathogens in planta.

摘要

葡萄皮尔斯病是最具破坏性的葡萄树干病害之一。[此处两个未给出的词]是与这种病害相关的两种已知真菌病原体。如今，针对葡萄皮尔斯病的生物防治剂主要基于使用如Vintec产品这类木霉属真菌寄生菌的菌株。本研究的目的是调查木质组织对葡萄皮尔斯病病原体的早期反应，并鉴定在复杂木质基质中可能与生物防治活性相关的代谢物。采用非靶向液相色谱 - 高分辨率质谱代谢组学方法结合光谱相似性网络来突出与植物对病原体和生物防治反应相关的化合物簇。去重复分析突出了甘油磷脂和多酚化合物的可能作用，后者主要属于芪类化合物。在[此处两个未给出的词]上评估的一些相关生物标志物的抗真菌活性表明，其中一些化合物可以在限制葡萄皮尔斯病病原体在植物体内发展方面发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/d5414d0d7f15/fmicb-13-835463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/314aabe7597b/fmicb-13-835463-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/d4fe7c6e7b4a/fmicb-13-835463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/db0afe7d447d/fmicb-13-835463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/fb35f2830b58/fmicb-13-835463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/d5414d0d7f15/fmicb-13-835463-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/314aabe7597b/fmicb-13-835463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/85b92d4ff076/fmicb-13-835463-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/d4fe7c6e7b4a/fmicb-13-835463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/db0afe7d447d/fmicb-13-835463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/fb35f2830b58/fmicb-13-835463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5088/8924477/d5414d0d7f15/fmicb-13-835463-g006.jpg

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