Lin Yen-Po, Chen Rou-Shayn, Chen Vincent Chiun-Fan, Liu Chun-Hsien, Chan Hsiao-Lung, Chang Ya-Ju
School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Front Bioeng Biotechnol. 2022 Mar 2;10:829772. doi: 10.3389/fbioe.2022.829772. eCollection 2022.
The strength of lower extremity is important for individuals to maintain balance and ambulation functions. The previous studies showed that individuals with Parkinson's disease suffered from fatigue and strength loss of central origin. The purpose of this study was to investigate the effect of lower extremities' cycling training on different components of force and fatigue in individuals with Parkinson's disease. Twenty-four individuals (13 males, 11 females, mean age: 60.58 ± 8.21 years) diagnosed with idiopathic Parkinson's disease were randomized into training and control groups. The maximum voluntary contraction (MVC) force, voluntary activation level (VA), and twitch force of knee extensors were measured using a custom-made system with surface electrical stimulation. The general, central, and peripheral fatigue indexes (GFI, CFI, and PFI) were calculated after a fatiguing cycling protocol. Subjects received 8 weeks of low resistance cycling training (training group) or self-stretching (control group) programs. Results showed that MVC, VA, and twitch force improved ( < 0.05) only in the training group. Compared to the baseline, central fatigue significantly improved in the training group, whereas peripheral fatigue showed no significant difference in two groups. The cycling training was beneficial for individuals with Parkinson's disease not only in muscle strengthening but also in central fatigue alleviation. Further in-depth investigation is required to confirm the effect of training and its mechanism on central fatigue.
下肢力量对于个体维持平衡和行走功能很重要。先前的研究表明，帕金森病患者存在源于中枢的疲劳和力量丧失。本研究的目的是调查下肢循环训练对帕金森病患者力量和疲劳不同组成部分的影响。24名被诊断为特发性帕金森病的个体（13名男性，11名女性，平均年龄：60.58±8.21岁）被随机分为训练组和对照组。使用定制的表面电刺激系统测量膝伸肌的最大自主收缩（MVC）力量、自主激活水平（VA）和抽搐力量。在进行疲劳性循环训练方案后计算一般、中枢和外周疲劳指数（GFI、CFI和PFI）。受试者接受8周的低阻力循环训练（训练组）或自我拉伸（对照组）方案。结果显示，仅训练组的MVC、VA和抽搐力量有所改善（<0.05）。与基线相比，训练组的中枢疲劳显著改善，而两组外周疲劳无显著差异。循环训练不仅对帕金森病患者的肌肉强化有益，而且对缓解中枢疲劳也有益。需要进一步深入研究以证实训练对中枢疲劳的影响及其机制。
