Liu He, Lu Jing, Jiang Qianzhou, Haapasalo Markus, Qian Junrong, Tay Franklin R, Shen Ya
Department of Stomatology, Affiliated Hospital of Jining Medical University, China.
Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Canada.
Bioact Mater. 2021 Oct 14;12:257-277. doi: 10.1016/j.bioactmat.2021.10.008. eCollection 2022 Jun.
Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis. As a component biological triad of tissue engineering (i.e., stem cells, growth factors and scaffolds), biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements. The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics. The favorable properties and limitations of biomaterials organized in naturally derived, host-derived and synthetic material categories were discussed. Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds, as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth.
在过去二十年中，再生牙髓治疗程序一直在迅速发展，并在临床牙髓病学中广泛应用。这些程序被视为传统治疗策略的重要辅助手段，用于治疗预后较差的坏死未成熟恒牙。作为组织工程的生物三联体组成部分（即干细胞、生长因子和支架），生物材料支架已展现出作为再生牙髓治疗程序中一种手段的临床潜力，并取得了显著进展。本综述的目的是全面概述用于再生牙髓治疗中作为支架的生物材料。讨论了天然来源、宿主来源和合成材料类别中生物材料的有利特性和局限性。深入探讨了过去五年发表的关于生物材料支架性能的临床前和临床研究，以及生物材料用于支架的应用现状挑战、未来前景，以及再生牙髓治疗程序中生物材料支架的临床评估。
