用于无创连续血糖监测的高度集成手表。

Highly integrated watch for noninvasive continual glucose monitoring.

作者信息

Chang Tianrui, Li Hu, Zhang Nianrong, Jiang Xinran, Yu Xinge, Yang Qingde, Jin Zhiyuan, Meng Hua, Chang Lingqian

机构信息

Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083 China.

Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.

出版信息

Microsyst Nanoeng. 2022 Feb 23;8:25. doi: 10.1038/s41378-022-00355-5. eCollection 2022.

Abstract

This article reports a highly integrated watch for noninvasive continual blood glucose monitoring. The watch employs a Nafion-coated flexible electrochemical sensor patch fixed on the watchband to obtain interstitial fluid (ISF) transdermally at the wrist. This reverse iontophoresis-based extraction method eliminates the pain and inconvenience that traditional fingerstick blood tests pose in diabetic patients' lives, making continual blood glucose monitoring practical and easy. All electronic modules, including a rechargeable power source and other modules for signal processing and wireless transmission, are integrated onto a watch face-sized printed circuit board (PCB), enabling comfortable wearing of this continual glucose monitor. Real-time blood glucose levels are displayed on the LED screen of the watch and can also be checked with the smartphone user interface. With 23 volunteers, the watch demonstrated 84.34% clinical accuracy in the Clarke error grid analysis (zones A + B). In the near future, commercial products could be developed based on this lab-made prototype to provide the public with noninvasive continual glucose monitoring.

摘要

本文报道了一款用于无创连续血糖监测的高度集成手表。该手表采用固定在表带上的涂有Nafion的柔性电化学传感器贴片,在手腕处经皮获取组织间液(ISF)。这种基于反向离子电渗疗法的提取方法消除了传统指尖采血检测给糖尿病患者生活带来的痛苦和不便,使连续血糖监测变得切实可行且简便。所有电子模块,包括可充电电源以及用于信号处理和无线传输的其他模块,都集成在一个表盘大小的印刷电路板(PCB)上,使得这款连续血糖监测仪佩戴起来很舒适。实时血糖水平显示在手表的LED屏幕上,也可以通过智能手机用户界面进行查看。在23名志愿者身上进行测试时,这款手表在克拉克误差网格分析(A + B区)中显示出84.34%的临床准确率。在不久的将来,可以基于这个实验室制作的原型开发商业产品,为公众提供无创连续血糖监测服务。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec4/8866463/3a1fcc45af27/41378_2022_355_Fig1_HTML.jpg

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