Shanghai Key Laboratory of Modern Optical Systems, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
Anal Sci. 2022 Feb;38(2):359-368. doi: 10.2116/analsci.21P148. Epub 2022 Mar 22.
Nifedipine is an antihypertensive chemical. The illegal addition of this chemical into Chinese traditional patent medicine (CTPM) is unstandardized and lacks regulation. It could bring serious side effects to patients, causing various symptoms. Therefore, accurate detection of nifedipine is very important for human health and the prevention of illegal additives. Surface-enhanced Raman spectroscopy (SERS) is a fast and sensitive fingerprint spectroscopic technique, which has been shown to be promising in drug detection. In this study, nifedipine in CTPM was determined qualitatively and quantitatively with SERS. Linear relationships between the concentrations of nifedipine and the intensities of the characteristic peaks were established. The results showed a linear relationship within the concentration range of 0.5-10 mg/L, and the lowest detectable concentration of nifedipine in CTPM was 0.1 mg/L (equivalent to 0.03% doping of nifedipine in CTPM). This method has shown a great potential in the detection of drugs illegally added to CTPM.
硝苯地平是一种降压化学物质。将这种化学物质非法添加到中药方剂（CTPM）中是不规范的，缺乏监管。它可能会给患者带来严重的副作用，引起各种症状。因此，准确检测硝苯地平对人类健康和预防非法添加剂非常重要。表面增强拉曼光谱（SERS）是一种快速灵敏的指纹光谱技术，已被证明在药物检测中具有很大的应用潜力。在这项研究中，采用 SERS 对 CTPM 中的硝苯地平进行了定性和定量测定。建立了硝苯地平浓度与特征峰强度之间的线性关系。结果表明，在 0.5-10mg/L 的浓度范围内呈线性关系，CTPM 中硝苯地平的最低检测浓度为 0.1mg/L（相当于 CTPM 中硝苯地平的 0.03%掺杂）。该方法在检测 CTPM 中非法添加的药物方面显示出巨大的潜力。
