Rossi Marta, Turati Federica, Strikoudi Panagiota, Ferraroni Monica, Parpinel Maria, Serraino Diego, Negri Eva, La Vecchia Carlo
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Celoria 22, 20133Milan, Italy.
Department of Medicine, Università degli Studi di Udine, 33100Udine, Italy.
Br J Nutr. 2023 May 14;129(9):1574-1580. doi: 10.1017/S0007114522000939. Epub 2022 Mar 23.
Circulating branched-chain amino acids (BCAA), a subgroup of the nine essential amino acids, has been associated with pancreatic cancer risk. The aim of this study is to estimate the relation between BCAA intake from diet and pancreatic cancer risk. We analysed data from a multicentric Italian case-control study, including 326 pancreatic cancer cases and 652 controls, matched to cases by study centre, sex and age. A validated FFQ was used to collect the participants' usual diet before cancer diagnosis (or hospital admission for controls) and to compute dietary intakes of various nutrients, including BCAA. OR and the corresponding CI were computed through logistic regression models conditioned on the matching variables and adjusted for major confounding factors, including total energy intake. We found a positive association between BCAA intake and pancreatic cancer risk (OR for the third quartile = 1·88, 95 % CI = 1·08, 3·26; OR for the fourth quartile = 2·17, 95 % CI = 1·17, 4·06), with a significant trend in risk. The association persisted after excluding subjects with diabetes and family history of pancreatic cancer and across strata of selected covariates. These data support and quantify the association between dietary BCAA and pancreatic cancer, previously suggested by studies on circulating BCAA.
循环支链氨基酸（BCAA）是九种必需氨基酸的一个亚组，与胰腺癌风险相关。本研究的目的是评估饮食中BCAA摄入量与胰腺癌风险之间的关系。我们分析了一项意大利多中心病例对照研究的数据，该研究包括326例胰腺癌病例和652例对照，根据研究中心、性别和年龄与病例进行匹配。使用经过验证的食物频率问卷（FFQ）收集参与者在癌症诊断前（或对照者入院前）的日常饮食，并计算包括BCAA在内的各种营养素的饮食摄入量。通过基于匹配变量的逻辑回归模型计算比值比（OR）和相应的置信区间（CI），并对包括总能量摄入在内的主要混杂因素进行调整。我们发现BCAA摄入量与胰腺癌风险之间存在正相关（第三四分位数的OR = 1.88，95%CI = 1.08，3.26；第四四分位数的OR = 2.17，95%CI = 1.17，4.06），风险有显著趋势。在排除患有糖尿病和有胰腺癌家族史的受试者以及选定协变量的各层后，该关联仍然存在。这些数据支持并量化了饮食中BCAA与胰腺癌之间的关联，此前关于循环BCAA的研究已有所提示。
