College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
College of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237499, China.
Mar Drugs. 2022 Feb 24;20(3):162. doi: 10.3390/md20030162.
In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete sp. WP1, yielded six novel amycolachromones A-F (-), together with five known analogues (-). Amycolachromones A-B (-) possessed unique dimer skeletons. The structures and relative configurations of compounds - were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A-F were also proposed.
在这项研究中，对深海放线菌 WP1 中一种链霉素抗性菌株进行了详细的化学研究，得到了六种新型的阿美霉素 A-F(-)，以及五种已知的类似物(-)。阿美霉素 A-B(-)具有独特的二聚体骨架。通过结合 X 射线晶体衍射分析的广泛光谱数据分析，阐明了化合物-的结构和相对构型。还提出了阿美霉素 A-F 的可能生物合成途径。
