CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China.
Mar Drugs. 2022 Feb 28;20(3):177. doi: 10.3390/md20030177.
An unusual sesquiterpene glycoside trichoacorside A () and two novel sorbicillinoid glycosides sorbicillisides A () and B (), together with a known compound sorbicillin (), were isolated and identified from the culture extract of an endophytic fungus EN-586, obtained from the marine red alga . Trichoacorside A () is the first representative of a glucosamine-coupled acorane-type sesquiterpenoid. Their structures were elucidated based on detailed interpretation of NMR and mass spectroscopic data. The absolute configurations were determined by X-ray crystallographic analysis, chemical derivatization, and DP4+ probability analysis. The antimicrobial activities of compounds - against several human, aquatic, and plant pathogens were evaluated.
从海洋红藻中内生真菌 EN-586 的培养物提取物中分离并鉴定出一种不寻常的倍半萜糖苷曲考索苷 A()和两种新型的索比菌素糖苷索比利西林 A()和 B()，以及一种已知化合物索比菌素()。曲考索苷 A()是第一个氨基葡萄糖偶联阿科烷型倍半萜的代表。基于对 NMR 和质谱数据的详细解释，确定了它们的结构。通过 X 射线晶体学分析、化学衍生化和 DP4+概率分析确定了绝对构型。评估了化合物-对几种人类、水生和植物病原体的抗菌活性。
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