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与海洋海绵相关的微生物:减缓衰老过程的生物活性分子宝库。

Microorganisms Associated with the Marine Sponge : A Reservoir of Bioactive Molecules to Slow Down the Aging Process.

作者信息

Said Hassane Charifat, Fouillaud Mireille, Le Goff Géraldine, Sklirou Aimilia D, Boyer Jean Bernard, Trougakos Ioannis P, Jerabek Moran, Bignon Jérôme, de Voogd Nicole J, Ouazzani Jamal, Gauvin-Bialecki Anne, Dufossé Laurent

机构信息

Laboratoire de Chimie et Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La Réunion, France.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.

出版信息

Microorganisms. 2020 Aug 20;8(9):1262. doi: 10.3390/microorganisms8091262.

Abstract

Aging research aims at developing therapies that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to slow aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge was investigated by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were recovered from the sponge, of which the phylum was the most abundant. In addition, 30 isolates from were selected and cultivated for identification and secondary metabolites production. The selected isolates were affiliated to the genera , , , , , , and unidentified genera related to the family . Crude extracts from selected microbial cultures were found to be active against seven clinically relevant targets (elastase, tyrosinase, catalase, sirtuin 1, Cyclin-dependent kinase 7 (CDK7), Fyn kinase and proteasome). These results highlight the potential of microorganisms associated with a marine sponge from Mayotte to produce anti-aging compounds. Future work will focus on the isolation and the characterization of bioactive compounds.

摘要

衰老研究旨在开发能够延缓正常衰老过程及某些相关病理状况的疗法。最近,许多天然产物中的化合物和提取物已被证明可延缓衰老和/或延长寿命。海洋海绵及其相关微生物已被发现能产生各种各样具有生物活性的次生代谢产物;然而,印度洋西南部的海洋海绵及其相关微生物的研究却少得多,尤其是在抗衰老活性方面。在本研究中,通过宏基因组分析对海洋海绵的微生物多样性进行了调查。从海绵中鉴定出了26个细菌门和2个古细菌门,其中 门最为丰富。此外,从 中挑选出30个分离株进行培养,以进行鉴定和次生代谢产物生产。所选分离株隶属于 属、 属、 属、 属、 属、 属、 属以及与 科相关的未鉴定属。研究发现,所选微生物培养物的粗提物对七种临床相关靶点(弹性蛋白酶、酪氨酸酶、过氧化氢酶、沉默调节蛋白1、细胞周期蛋白依赖性激酶7(CDK7)、Fyn激酶和蛋白酶体)具有活性。这些结果凸显了马约特岛一种海洋海绵相关微生物产生抗衰老化合物的潜力。未来的工作将集中于生物活性化合物的分离和表征。

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