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子宫内膜癌治疗方案后银和金纳米颗粒在伤口愈合过程中的益处。

Benefit of Silver and Gold Nanoparticles in Wound Healing Process after Endometrial Cancer Protocol.

作者信息

Toczek Jakub, Sadłocha Marcin, Major Katarzyna, Stojko Rafał

机构信息

Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia in Katowice, Markiefki 87, 40-211 Katowice, Poland.

出版信息

Biomedicines. 2022 Mar 16;10(3):679. doi: 10.3390/biomedicines10030679.

Abstract

It is intractable to manage the vast majority of wounds in a classical surgical manner, however if silver, likewise gold and its representative nanoparticles, can lead to the amelioration of the wound healing process after extensive procedures, they should be employed in the current gynecological practice as promptly as possible. Most likely due to its antimicrobial properties, silver is usually applied as an additional component in the wound healing process. In wound management, we obtained various aspects that can lead to impaired wound healing; the crucial aspect for the wound milieu is to prevent the offending agents from occurring. The greatest barrier to healing is represented by the bacterial biofilm, which can occur naturally or in other ways. Biofilm bacteria can produce extracellular polymers, which can then resist concentrated anti-bacterial treatment. The published literature on the use of silver nanoparticles' utilization in wound healing becomes slightly heterogenous and requires us in difficult moments to set up proper treatment guidelines.

摘要

以传统外科方式处理绝大多数伤口是棘手的,然而,如果银,同样还有金及其代表性纳米颗粒,在广泛的手术操作后能促进伤口愈合过程的改善,那么它们就应尽快应用于当前的妇科实践中。银很可能因其抗菌特性,通常在伤口愈合过程中作为一种附加成分使用。在伤口处理中,我们了解到有多个方面可能导致伤口愈合受损;伤口环境的关键在于防止有害因素的出现。愈合的最大障碍是细菌生物膜,它可能自然形成或以其他方式产生。生物膜细菌能产生细胞外聚合物,进而能抵抗浓缩抗菌治疗。关于银纳米颗粒在伤口愈合中应用的已发表文献略显参差不齐,这要求我们在困难时刻制定恰当的治疗指南。

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