Paladini Federica, Pollini Mauro
Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Materials (Basel). 2019 Aug 9;12(16):2540. doi: 10.3390/ma12162540.
Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in the European Union and European Economic Area (EEA) can be estimated as the cumulative burden of tuberculosis, influenza, and human immunodeficiency virus (HIV). In wound management, the control of infections represents a crucial issue and a multi-billion dollar industry worldwide. For diabetic wounds ulcers, in particular, infections are related to the majority of amputations in diabetic patients, which today represent an increasing number of the elderly. The greatest barrier to healing is represented by the biofilm, an organized consortium of bacteria encapsulated in a self-produced extracellular polymeric substance with high resistance to conventional antimicrobial therapies. There is an urgent need for novel anti-biofilm strategies and novel antimicrobial agents and, in this scenario, silver nanotechnology has received tremendous attention in recent years in therapeutically enhanced healthcare. Due to its intrinsic therapeutic properties and the broad-spectrum antimicrobial efficacy, silver nanoparticles have opened new horizons towards novel approaches in the control of infections in wound healing. This review aims at providing the reader with an overview of the most recent progress in silver nanotechnology, with a special focus on the role of silver in the wound healing process.
最近的数据报告称，在欧盟和欧洲经济区（EEA），与抗生素耐药菌相关的感染负担可估计为结核病、流感和人类免疫缺陷病毒（HIV）的累积负担。在伤口处理方面，感染的控制是一个关键问题，并且在全球是一个价值数十亿美元的产业。特别是对于糖尿病伤口溃疡，感染与糖尿病患者的大多数截肢有关，如今糖尿病患者中老年人数目不断增加。愈合的最大障碍是生物膜，它是由细菌组成的有组织的聚集体，被包裹在自身产生的对传统抗菌疗法具有高度抗性的细胞外聚合物中。迫切需要新的抗生物膜策略和新型抗菌剂，在这种情况下，银纳米技术近年来在治疗性增强医疗保健方面受到了极大关注。由于其固有的治疗特性和广谱抗菌功效，银纳米颗粒为伤口愈合中感染控制的新方法开辟了新视野。本综述旨在为读者提供银纳米技术最新进展的概述，特别关注银在伤口愈合过程中的作用。
