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COVID-19感染合并妊娠期弥散性血管内凝血——两例报告

COVID-19 Infection Complicated by Disseminated Intravascular Coagulation during Pregnancy-Two Cases Report.

作者信息

Skalska-Świstek Małgorzata, Huras Hubert, Jaworowski Andrzej Piotr, Świstek Rafał, Kołak Magdalena

机构信息

Department of Obstetrics and Perinatology, Medical College, Jagiellonian University, 23 Kopernika Str., 31-501 Krakow, Poland.

Department of Anaesthesiology and Intensive Therapy, University Hospital in Krakow, 2 Jakubowskiego Str., 30-688 Krakow, Poland.

出版信息

Diagnostics (Basel). 2022 Mar 8;12(3):655. doi: 10.3390/diagnostics12030655.

Abstract

Coagulopathies are one of the obstetric complications affecting the period of pregnancy, childbirth, and puerperium. One of the more severe and complex disorders of the haemostatic system is the disseminated intravascular coagulation syndrome (DIC), in which generalised activation of the coagulation system and activation of inflammatory cells occurs. DIC syndrome was observed in patients whose pregnancy was complicated by SARS-CoV-2 infection. Both the course of these cases and literature review indicate that particular notice should be paid to laboratory parameters of the coagulation system, closely monitoring the well-being of the foetus and, in the situation of acute DIC development, it is advised to deliver a baby and initiate intensive therapy.

摘要

凝血功能障碍是影响妊娠期、分娩期及产褥期的产科并发症之一。止血系统较为严重和复杂的疾病之一是弥散性血管内凝血综合征(DIC),其中会发生凝血系统的全身性激活和炎症细胞的激活。在妊娠合并新型冠状病毒感染的患者中观察到了DIC综合征。这些病例的病程及文献综述均表明,应特别关注凝血系统的实验室参数,密切监测胎儿状况,在急性DIC发生时,建议分娩并启动强化治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13bb/8947359/4f003a98a584/diagnostics-12-00655-g001.jpg

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