Institute of Translational Medicine, Semmelweis University Budapest, Tüzoltó u 37-47, 1094 Budapest, Hungary.
Int J Mol Sci. 2022 Mar 10;23(6):2972. doi: 10.3390/ijms23062972.
The prevailing general view of acute-phase proteins (APPs) is that they are produced by the liver in response to the stress of the body as part of a systemic acute-phase response. We demonstrated a coordinated, local production of these proteins upon cell stress by the stressed cells. The local, stress-induced APP production has been demonstrated in different tissues (kidney, breast cancer) and with different stressors (hypoxia, fibrosis and electromagnetic heat). Thus, this local acute-phase response (APR) seems to be a universal mechanism. APP production is an ancient defense mechanism observed in nematodes and fruit flies as well. Local APP production at the tissue level is also supported by sporadic literature data for single proteins; however, the complex, coordinated, local appearance of this stress response has been first demonstrated only recently. Although a number of literature data are available for the local production of single acute-phase proteins, their interpretation as a local, coordinated stress response is new. A better understanding of the role of APPs in cellular stress response may also be of diagnostic/prognostic and therapeutic significance.
急性期蛋白（APPs）的普遍观点是，它们是肝脏在身体应激时产生的，作为全身性急性期反应的一部分。我们通过应激细胞证明了这些蛋白质在细胞应激时的协调、局部产生。已经在不同组织（肾脏、乳腺癌）和不同应激源（缺氧、纤维化和电磁热）中证明了局部应激诱导的 APP 产生。因此，这种局部急性期反应（APR）似乎是一种普遍机制。在线虫和果蝇中也观察到了 APP 产生这种古老的防御机制。在组织水平上局部 APP 产生也得到了一些关于单个蛋白质的零星文献数据的支持；然而，这种应激反应的复杂、协调的局部出现只是最近才首次得到证明。虽然有许多关于单个急性期蛋白局部产生的文献数据，但将其解释为局部协调的应激反应是新的。更好地理解 APP 在细胞应激反应中的作用也可能具有诊断/预后和治疗意义。
