Service de Dermatologie, CIC 1413, CRCINA Inserm 1232, University Hospital Nantes, Nantes, France.
Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.
J Eur Acad Dermatol Venereol. 2018 May;32(5):812-819. doi: 10.1111/jdv.14820. Epub 2018 Feb 15.
Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.
To assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome.
Two consensus meetings of five European dermatologists and a comprehensive literature search on exposome factors triggering acne served as a basis for this review.
Acne exposome was defined as the sum of all environmental factors influencing the occurrence, duration and severity of acne. Exposome factors impact on the response and the frequency of relapse to treatments by interacting with the skin barrier, sebaceous gland, innate immunity and cutaneous microbiota. They may be classified into the following six main categories: nutrition, psychological and lifestyle factors, occupational factors including cosmetics, as well as pollutants, medication and climatic factors. Moreover, practical considerations for the dermatologist's clinical practice are proposed.
Exposome factors including nutrition, medication, occupational factors, pollutants, climatic factors, and psychosocial and lifestyle factors may impact on the course and severity of acne and on treatment efficacy. Identifying and reducing the impact of exposome is important for an adequate acne disease management.
痤疮是皮肤科就诊的主要原因之一。其严重程度和治疗反应可能会受到各种外部因素或暴露组的影响。
评估环境因素对痤疮的影响，并全面概述痤疮暴露组。
本综述的依据为 5 位欧洲皮肤科医生的两次共识会议，以及针对触发痤疮的暴露组因素的全面文献检索。
痤疮暴露组被定义为影响痤疮发生、持续时间和严重程度的所有环境因素的总和。暴露组因素通过与皮肤屏障、皮脂腺、先天免疫和皮肤微生物群相互作用，影响治疗的反应和复发频率。它们可分为以下六大类：营养、心理和生活方式因素、职业因素（包括化妆品）以及污染物、药物和气候因素。此外，还为皮肤科医生的临床实践提出了实际注意事项。
暴露组因素包括营养、药物、职业因素、污染物、气候因素、心理社会和生活方式因素，可能会影响痤疮的病程和严重程度，以及治疗效果。确定和减少暴露组的影响对于痤疮的充分管理很重要。
