Biju Aswathi K, B Nisha, Shanmugam Rajeshkumar
Nanobiomedicine Lab, Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Community Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Aug 29;16(8):e68159. doi: 10.7759/cureus.68159. eCollection 2024 Aug.
Introduction Acne vulgaris is a common skin problem caused by inflammation of the sebaceous glands and hair follicles as a result of hormonal fluctuations, bacteria, and overproduction of oil. The plant () has been investigated for possible medical uses. Its anti-inflammatory, antibacterial, and antioxidant qualities are well recognised, and they may be applied to treat several diseases. This study investigates the plant's phytochemicals for their effectiveness in treating acne. Methods The Indian Medicinal Plants, Phytochemistry and Therapeutics (IMPPAT) database was utilised to extract the phytochemicals from . The absorption, distribution, metabolism, and excretion (ADME) analysis was conducted using the online tool SwissADME. The SwissTargetPrediction tool determines the potential targets of these phytochemicals. Targets for acne have been identified using the Open Targets Platform database. The common targets of and acne were identified using the Venn diagram drawing tool Venny 2.1.0, and a protein-protein interaction (PPI) network was built using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database. Following that, hub genes were identified by Cytoscape 3.10.2. The web tool ShinyGO 0.80 has enabled simpler evaluation of enrichment analysis for these hub genes. Results Five genes were shown to be key targets because they are directly engaged in the relaxin signalling pathway by pathway analysis: epidermal growth factor receptor (EGFR) and various matrix metalloproteinases (MMPs) (MMP1, MMP2, MMP9, and MMP13). The phytochemicals found in , including quercetin, rhamnetin, hirsutidin, and (+)-leucocyanidin, target these key genes. Conclusion This study highlights the potential of as a multi-target therapeutic agent for acne vulgaris. By targeting key genes in the relaxin signalling pathway, the phytochemicals from present a promising approach for acne management.
引言 寻常痤疮是一种常见的皮肤问题，由皮脂腺和毛囊因激素波动、细菌以及油脂过度分泌而引发炎症所致。对[植物名称]进行了潜在医学用途的研究。其抗炎、抗菌和抗氧化特性已得到充分认可，可用于治疗多种疾病。本研究考察该植物的植物化学物质治疗痤疮的有效性。
方法 利用《印度药用植物、植物化学与治疗学》（IMPPAT）数据库从[植物名称]中提取植物化学物质。使用在线工具SwissADME进行吸收、分布、代谢和排泄（ADME）分析。SwissTargetPrediction工具确定这些植物化学物质的潜在靶点。利用开放靶点平台数据库确定痤疮的靶点。使用维恩图绘制工具Venny 2.1.0确定[植物名称]和痤疮的共同靶点，并使用检索相互作用基因/蛋白质的搜索工具（STRING）数据库构建蛋白质-蛋白质相互作用（PPI）网络。随后，通过Cytoscape 3.10.2确定枢纽基因。网络工具ShinyGO 0.80使对这些枢纽基因的富集分析评估更为简便。
结果 通路分析显示，五个基因是关键靶点，因为它们直接参与松弛素信号通路：表皮生长因子受体（EGFR）和各种基质金属蛋白酶（MMPs）（MMP1、MMP2、MMP9和MMP13）。[植物名称]中发现的植物化学物质，包括槲皮素、鼠李素、异鼠李素和（+）-无色花青素，靶向这些关键基因。
结论 本研究突出了[植物名称]作为寻常痤疮多靶点治疗药物的潜力。通过靶向松弛素信号通路中的关键基因，[植物名称]中的植物化学物质为痤疮管理提供了一种有前景的方法。
