Zafar Bushra, Campbell Jack, Cooke Jake, Skirtach Andre G, Volodkin Dmitry
Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.
Nanotechnology Laboratory, Faculty of Bioscience Engineering, Ghent University, 9000 Ghent, Belgium.
Micromachines (Basel). 2022 Mar 19;13(3):473. doi: 10.3390/mi13030473.
Former studies have demonstrated a strong interest toward the crystallization of CaCO polymorphs in solution. Nowadays, CaCO crystallization on solid surfaces is extensively being studied using biomolecules as substrates for the control of the growth aiming at various applications of CaCO. Calcium carbonate exists in an amorphous state, as three anhydrous polymorphs (aragonite, calcite and vaterite), and as two hydrated polymorphs (monohydrocalcite and ikaite). The vaterite polymorph is considered as one of the most attractive forms due to its large surface area, biocompatibility, mesoporous nature, and other features. Based on physical or chemical immobilization approaches, vaterite can be grown directly on solid surfaces using various (bio)molecules, including synthetic polymers, biomacromolecules such as proteins and peptides, carbohydrates, fibers, extracellular matrix components, and even biological cells such as bacteria. Herein, the progress on the modification of solid surfaces by vaterite CaCO crystals is reviewed, focusing on main findings and the mechanism of vaterite growth initiated by various substances mentioned above, as well as the discussion of the applications of such modified surfaces.
先前的研究已表明对溶液中碳酸钙多晶型物的结晶有着浓厚兴趣。如今，人们广泛研究碳酸钙在固体表面的结晶过程，以生物分子作为控制生长的底物，旨在实现碳酸钙的各种应用。碳酸钙以无定形状态存在，有三种无水多晶型物（文石、方解石和球霰石）以及两种水合多晶型物（一水碳酸钙和柱霰石）。球霰石多晶型物因其较大的表面积、生物相容性、介孔性质及其他特性，被认为是最具吸引力的形式之一。基于物理或化学固定方法，球霰石可以使用各种（生物）分子直接在固体表面生长，这些分子包括合成聚合物、生物大分子如蛋白质和肽、碳水化合物、纤维、细胞外基质成分，甚至生物细胞如细菌。在此，综述了球霰石碳酸钙晶体对固体表面改性的进展，重点关注上述各种物质引发球霰石生长的主要发现和机制，以及对此类改性表面应用的讨论。
