Persano Francesca, Nobile Concetta, Piccirillo Clara, Gigli Giuseppe, Leporatti Stefano
Department of Mathematics and Physics, University of Salento, 73100 Lecce, Italy.
CNR Nanotec-Institute of Nanotechnology, 73100 Lecce, Italy.
Nanomaterials (Basel). 2022 Apr 28;12(9):1494. doi: 10.3390/nano12091494.
Calcium carbonate (CaCO) particles represent an appealing choice as a drug delivery system due to their biocompatibility, biodegradability, simplicity and cost-effectiveness of manufacturing, and stimulus-responsiveness. Despite this, the synthesis of CaCO particles with controlled size in the nanometer range via a scalable manufacturing method remains a major challenge. Here, by using a co-precipitation technique, we investigated the impact on the particle size of different synthesis parameters, such as the salt concentration, reaction time, stirring speed, and temperature. Among them, the salt concentration and temperature resulted in having a remarkable effect on the particle size, enabling the preparation of well-dispersed spherical nanoparticles with a size below 200 nm. Upon identification of optimized synthesis conditions, the encapsulation of the antitumoral agent resveratrol into CaCO nanoparticles, without significantly impacting the overall size and morphology, has been successfully achieved.
碳酸钙（CaCO₃）颗粒因其生物相容性、可生物降解性、制造的简易性和成本效益以及刺激响应性，成为药物递送系统的一个有吸引力的选择。尽管如此，通过可扩展的制造方法合成具有纳米级可控尺寸的碳酸钙颗粒仍然是一个重大挑战。在此，我们采用共沉淀技术，研究了不同合成参数（如盐浓度、反应时间、搅拌速度和温度）对颗粒尺寸的影响。其中，盐浓度和温度对颗粒尺寸有显著影响，能够制备出尺寸低于200 nm的分散良好的球形纳米颗粒。在确定优化的合成条件后，已成功地将抗肿瘤剂白藜芦醇封装到碳酸钙纳米颗粒中，且未显著影响其整体尺寸和形态。
