Basti Aliakbar Tofangchi Kalle, Jonoobi Mehdi, Sepahvand Sima, Ashori Alireza, Siracusa Valentina, Rabie Davood, Mekonnen Tizazu H, Naeijian Fatemeh
Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj 77871-31587, Iran.
Department of Chemical Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Polymers (Basel). 2022 Mar 17;14(6):1207. doi: 10.3390/polym14061207.
The aim of this research was to fabricate a burn dressing in the form of hydrogel films constructed with cellulose nanofibers (CNF) that has pain-relieving properties, in addition to wound healing. In this study, the hydrogels were prepared in the form of film. For this, CNF at weight ratios of 1, 2, and 3 wt.%, 1 wt.% of hydroxyethyl cellulose (HEC), and citric acid (CA) crosslinker with 10 and 20 wt.% were used. FE-SEM analysis showed that the structure of the CNF was preserved after hydrogel preparation. Cationization of CNF by CHNOCl was confirmed by FTIR spectroscopy. The drug release analysis results showed a linear relationship between the amount of absorption and the concentration of the drug. The MTT test (assay protocol for cell viability and proliferation) showed the high effectiveness of cationization of CNF and confirmed the non-toxicity of the resulting hydrogels.
本研究的目的是制备一种以纤维素纳米纤维（CNF）构建的水凝胶膜形式的烧伤敷料，该敷料除了具有伤口愈合功能外，还具有止痛特性。在本研究中，水凝胶以薄膜形式制备。为此，使用了重量比为1 wt.%、2 wt.%和3 wt.%的CNF、1 wt.%的羟乙基纤维素（HEC）以及10 wt.%和20 wt.%的柠檬酸（CA）交联剂。场发射扫描电子显微镜（FE-SEM）分析表明，水凝胶制备后CNF的结构得以保留。傅里叶变换红外光谱（FTIR）证实了CNF经CHNOCl阳离子化。药物释放分析结果表明，吸收量与药物浓度之间呈线性关系。MTT试验（细胞活力和增殖的检测方案）表明CNF阳离子化具有高效性，并证实了所得水凝胶的无毒性。
