金刚烷胺对人博尔纳病病毒感染的体外和体内显著疗效。评芬克等人的《金刚烷胺抑制 SARS-CoV-2 的体外活性》。2021 年，539 期。
Prominent Efficacy of Amantadine against Human Borna Disease Virus Infection In Vitro and In Vivo. Comment on Fink et al. Amantadine Inhibits SARS-CoV-2 In Vitro. 2021, , 539.
机构信息
Joint Senior Scientists, Freelance Bornavirus Workgroup, 14163 Berlin, Germany.
Ameos Clinic Hildesheim Psychotherapy and Psychiatry, 31135 Hildesheim, Germany.
出版信息
Viruses. 2022 Feb 28;14(3):494. doi: 10.3390/v14030494.
Abstract
Amantadine (1-amino-adamantane) is a versatile antiviral compound which has been licensed for decades against influenza viruses. During the Corona pandemic, its effect to inhibit SARS-CoV-2 in vitro has been investigated. However, an in vivo oral inapplicability was concluded due to ID doses exceeding eight times the estimated maximum tolerable plasma levels reached by 600 mg orally daily. In contrast, amantadine has been shown to be extraordinarily efficient against human neurotropic Borna disease virus (BoDV-1), presenting with both anti-depressive and anti-viral efficacy against a placebo, achieved by a well-tolerated low oral daily dose of 200 mg amantadine.
摘要
金刚烷胺（1-氨基-金刚烷）是一种用途广泛的抗病毒化合物，已获得许可数十年用于对抗流感病毒。在冠状病毒大流行期间，已经研究了其抑制 SARS-CoV-2 的体外效果。然而，由于 ID 剂量超过估计的最大耐受血浆水平的 8 倍，每日口服 600 毫克，因此结论是体内口服不适用。相比之下，金刚烷胺对人类嗜神经性博尔纳病病毒（BoDV-1）表现出极高的效率，具有抗抑郁和抗病毒功效，优于安慰剂，每日口服 200 毫克金刚烷胺的低剂量即可很好地耐受。
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