金刚烷胺对博尔纳病病毒没有抗病毒活性。

Amantadine does not have antiviral activity against Borna disease virus.

作者信息

Cubitt B, de la Torre J C

机构信息

Department of Neuropharmacology, Scripps Research Institute, La Jolla, California, USA.

出版信息

Arch Virol. 1997;142(10):2035-42. doi: 10.1007/s007050050220.

DOI:10.1007/s007050050220

PMID:9413511

Abstract

We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 microM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.

摘要

我们在多种培养细胞系统中研究了金刚烷胺（AD）对博尔纳病病毒（BDV）的抗病毒活性。我们提供的证据表明，浓度在5至10微摩尔范围内的AD对BDV没有抗病毒活性。用AD处理BDV感染的细胞六天，既没有使感染细胞数量减少，也没有使BDV RNA或蛋白质的稳态水平降低。此外，在感染前用AD处理细胞并不影响BDV的增殖，而甲型流感病毒的产量相对于未处理的对照细胞所获得的产量不到1%。