Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People's Republic of China.
Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People's Republic of China.
Drug Des Devel Ther. 2022 Mar 21;16:739-748. doi: 10.2147/DDDT.S356880. eCollection 2022.
To investigate the effect of intravenous infusion of lidocaine compared with ultrasound-guided transverse abdominal plane (TAP) block on the quality of postoperative recovery and analgesic effect in patients undergoing bariatric surgery.
Ninety-nine ASA II-III patients scheduled for elective laparoscopic bariatric surgery were randomized into the lidocaine group (group L), transverse abdominal plane block group (group T), and control group (group C). Group L: a loading dose of 1.5 mg/kg lidocaine was given at induction, followed by 2 mg·kg·h maintenance until the end of surgery. Group T: ultrasound-guided bilateral administration of 0.25% ropivacaine in the transverse abdominal plane was given after induction of general anesthesia. Group C: no additional treatment was performed. Quality of recovery-40 (QoR-40) was assessed at 24 h after surgery. Consumption of propofol and remifentanil, visual analog scale (VAS) pain scores at rest at 0, 6, 12, and 24 h postoperatively, time to return of intestinal function, use of remedial analgesics within 24 h after surgery, adverse reactions were recorded.
Compared with Group C, Group L and Group T had higher QoR-40 scores at 24 h postoperatively, and the difference was statistically significant (=0.002 and =0.003, respectively). However, there was no difference between Group L and Group T (=0.128). In addition, compared with those of Group T and Group C, VAS scores at 12 h and 24 h postoperatively were lower in Group L ( <0.0166).
Both intravenous infusion of lidocaine and ultrasound-guided TAP block provided good postoperative recovery and postoperative analgesia for patients with bariatric surgery, and intravenous infusion of lidocaine provided better analgesia at 12 h and 24 h postoperatively compared with TAP block.
研究与超声引导腹横平面(TAP)阻滞相比,利多卡因静脉输注对接受减重手术患者术后恢复质量和镇痛效果的影响。
99 名 ASA II-III 级择期腹腔镜减重手术患者随机分为利多卡因组(L 组)、TAP 阻滞组(T 组)和对照组(C 组)。L 组:诱导时给予负荷剂量 1.5mg/kg 利多卡因,然后以 2mg·kg·h 的速度维持至手术结束。T 组:全身麻醉诱导后行双侧超声引导 TAP 0.25%罗哌卡因注射。C 组:不进行额外治疗。术后 24 小时评估恢复质量 40 分(QoR-40)。记录术后 0、6、12 和 24 小时静息时的丙泊酚和瑞芬太尼消耗量、视觉模拟评分(VAS)疼痛评分、肠功能恢复时间、术后 24 小时内补救性镇痛药物的使用情况及不良反应。
与 C 组相比,L 组和 T 组术后 24 小时 QoR-40 评分较高,差异有统计学意义(=0.002 和=0.003)。但 L 组和 T 组之间差异无统计学意义(=0.128)。此外,与 T 组和 C 组相比,L 组术后 12 小时和 24 小时的 VAS 评分较低(<0.0166)。
静脉输注利多卡因和超声引导 TAP 阻滞均为减重手术患者提供了良好的术后恢复和术后镇痛效果,与 TAP 阻滞相比,静脉输注利多卡因在术后 12 小时和 24 小时提供了更好的镇痛效果。