Lu Huiqi, Hirst Jane, Yang Jenny, Mackillop Lucy, Clifton David
Department of Engineering Science Institute of Biomedical Engineering University of Oxford Oxford UK.
Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK.
Healthc Technol Lett. 2022 Mar 13;9(1-2):1-8. doi: 10.1049/htl2.12022. eCollection 2022 Feb-Apr.
Mothers with gestational diabetes are at increased risk of giving birth by caesarean section. A standardised assessment method may help to guide in recommendations in planning caesarean birth. We analysed 203 women with gestational diabetes managed in a single centre and developed an aggregate heuristic risk score. Among 155 women who had not had a previous caesarean birth, five risk factors (previous birth, weight gain during pregnancy, mother's height, and glycated haemoglobin and fasting blood glucose results at the beginning of pregnancy) were found associated with primary caesarean birth. Risk of primary caesarean birth in low-risk women (score 0-1) was 13.8%, medium-risk (score 2-3) 24.5% and high risk (score ≥ 4) 66.7%. The area under the receiver operating characteristic (AUROC) for primary caesarean birth prediction is 0.726 ± 0.003. Machine learning models were then deployed on 97 patients to explore the role of temporal blood glucose in predicting caesarean birth, achieving an AUROC of 0.857 ± 0.008. In conclusion, Oxford caesarean prediction score could help clinicians counselling women with gestational diabetes about their individual risk of primary caesarean birth. Temporal blood glucose measurements may improve the prediction subject to further validation.
患有妊娠期糖尿病的母亲剖宫产分娩的风险增加。一种标准化的评估方法可能有助于指导剖宫产分娩计划的建议。我们分析了在单一中心接受治疗的203例妊娠期糖尿病女性,并制定了一个综合启发式风险评分。在155例既往未行剖宫产的女性中,发现五个风险因素(既往分娩情况、孕期体重增加、母亲身高、妊娠初期糖化血红蛋白和空腹血糖结果)与首次剖宫产有关。低风险女性(评分0 - 1)首次剖宫产的风险为13.8%,中等风险(评分2 - 3)为24.5%,高风险(评分≥4)为66.7%。预测首次剖宫产的受试者工作特征曲线下面积(AUROC)为0.726±0.003。然后,将机器学习模型应用于97例患者,以探讨血糖动态变化在预测剖宫产中的作用,AUROC达到0.857±0.008。总之,牛津剖宫产预测评分可帮助临床医生为患有妊娠期糖尿病的女性提供关于其首次剖宫产个体风险的咨询。血糖动态测量可能会改善预测效果,但有待进一步验证。