Zhang Wei, Qian Yue, Jin Xue, Wang Yixian, Mu Lili, Jiang Zhixia
Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, People's Republic of China.
Guizhou Nursing Vocational College, Guiyang, People's Republic of China.
Int J Gen Med. 2022 Mar 19;15:3167-3182. doi: 10.2147/IJGM.S353610. eCollection 2022.
SIRT7 has been shown to be expressed in many cancer types, including clear cell renal cell carcinoma (KIRC), but its functional role in this oncogenic context remains to be firmly defined. This study was designed to explore correlations between SIRT7 and KIRC characteristics using the TCGA database.
Relationships between SIRT7 expression and KIRC patient clinicopathological characteristics were assessed through Kruskal-Wallis tests, Wilcoxon signed-rank tests, and logistic regression analyses. Area under the ROC curve (AUC) values were used to assess the prognostic value of SIRT7 as a means of classifying clear cell renal cell carcinoma patients. The functional role of SIRT7 in this cancer type was assessed through GO/KEGG enrichment analyses and immune cell infiltration analyses.
In KIRC patients, higher levels of SIRT7 expression were associated with Race, M stage, T stage (all P < 0.05). SIRT7 offered significant diagnostic value in ROC curve analyses (AUC = 0.912), and elevated SIRT7 levels were linked to worse patient overall survival (OS; P < 0.001). The expression of SIRT7 was independently related with KIRC patient OS (HR: 1.827; 95% CI: 1.346-2.481; P<0.001). In GO/KEGG analyses, SIRT7 was found to be associated with ubiquitin-mediated proteolysis and nucleotide excision repair. Higher SIRT7 expression was related to the enhanced infiltration of certain immune cells.
Increased SIRT7 expression was associated with a worse KIRC patient prognosis, and immune infiltrates, suggesting it may offer value as a prognostic biomarker for this cancer type.
SIRT7已被证明在多种癌症类型中表达，包括肾透明细胞癌（KIRC），但其在这种致癌环境中的功能作用仍有待明确界定。本研究旨在利用TCGA数据库探索SIRT7与KIRC特征之间的相关性。
通过Kruskal-Wallis检验、Wilcoxon符号秩检验和逻辑回归分析评估SIRT7表达与KIRC患者临床病理特征之间的关系。ROC曲线下面积（AUC）值用于评估SIRT7作为肾透明细胞癌患者分类手段的预后价值。通过GO/KEGG富集分析和免疫细胞浸润分析评估SIRT7在这种癌症类型中的功能作用。
在KIRC患者中，较高水平的SIRT7表达与种族、M分期、T分期相关（所有P<0.05）。SIRT7在ROC曲线分析中具有显著的诊断价值（AUC=0.912），SIRT7水平升高与患者总生存期较差相关（P<0.001）。SIRT7的表达与KIRC患者的总生存期独立相关（HR：1.827；95%CI：1.346-2.481；P<0.001）。在GO/KEGG分析中，发现SIRT7与泛素介导的蛋白水解和核苷酸切除修复相关。较高的SIRT7表达与某些免疫细胞的浸润增强有关。
SIRT7表达增加与KIRC患者预后较差及免疫浸润相关，表明它可能作为这种癌症类型的预后生物标志物具有价值。
