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孕产妇及先天性梅毒的延迟诊断:一场未被认识的流行病?

Delayed diagnosis of maternal and congenital syphilis: An unrecognized epidemic?

作者信息

Dionisopoulos Zachary, Kakkar Fatima, Blanchard Ana C

机构信息

Paediatrics Residency Program, Department of Paediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, QC.

Division of Infectious Diseases, Department of Paediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, QC.

出版信息

Can Commun Dis Rep. 2022 Feb 24;48(2-3):115-118. doi: 10.14745/ccdr.v48i23a10.

DOI:10.14745/ccdr.v48i23a10
PMID:35342371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8890596/
Abstract

Syphilis is an infection caused by spirochetes. The diagnosis of this sexually transmitted disease may be missed, partly due to the painless nature of genital ulcers in its primary stage. Women in Canada are screened for syphilis in their first trimester of pregnancy, but late pregnancy testing is not done in all provinces to date; therefore, undetected vertical transmission of syphilis may occur. This case emphasizes the importance of recognizing congenital syphilis in infants and young children with unexplained growth problems and biochemical and hematological abnormalities. Congenital syphilis remains a rare diagnosis, but in the context of increased syphilis rates in Canada during recent years, clinicians should consider this diagnosis in infants presenting with compatible clinical manifestations.

摘要

梅毒是一种由螺旋体引起的感染。这种性传播疾病的诊断可能会被漏诊,部分原因是其一期生殖器溃疡无痛的特性。加拿大的女性在怀孕的头三个月会接受梅毒筛查,但截至目前并非所有省份都会在孕晚期进行检测;因此,梅毒可能会发生未被检测到的垂直传播。该病例强调了在患有不明原因生长问题以及生化和血液学异常的婴幼儿中识别先天性梅毒的重要性。先天性梅毒仍然是一种罕见的诊断,但鉴于近年来加拿大梅毒发病率上升,临床医生对于出现符合临床表现的婴儿应考虑这一诊断。

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Delayed diagnosis of maternal and congenital syphilis: An unrecognized epidemic?孕产妇及先天性梅毒的延迟诊断:一场未被认识的流行病?
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Asian Biomed (Res Rev News). 2023 Aug 7;17(1):1-2. doi: 10.2478/abm-2023-0037. eCollection 2023 Feb.

本文引用的文献

1
High Incidence of Congenital Syphilis in New Zealand: A New Zealand Pediatric Surveillance Unit Study.新西兰先天性梅毒高发:新西兰儿科监测单位研究。
Pediatr Infect Dis J. 2022 Jan 1;41(1):66-71. doi: 10.1097/INF.0000000000003233.
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Missed Opportunities for Prevention of Congenital Syphilis - United States, 2018.预防先天性梅毒的错失机会 - 美国,2018 年。
MMWR Morb Mortal Wkly Rep. 2020 Jun 5;69(22):661-665. doi: 10.15585/mmwr.mm6922a1.
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Infectious and congenital syphilis in Canada, 2010-2015.2010 - 2015年加拿大的感染性和先天性梅毒
Can Commun Dis Rep. 2018 Feb 1;44(2):43-48. doi: 10.14745/ccdr.v44i02a02.
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Congenital syphilis: A guide to diagnosis and management.先天性梅毒:诊断与管理指南
Paediatr Child Health. 2000 Nov;5(8):463-9. doi: 10.1093/pch/5.8.463.
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Congenital syphilis after maternal treatment for syphilis during pregnancy.孕期母亲梅毒治疗后发生的先天性梅毒。
Am J Obstet Gynecol. 2002 Mar;186(3):569-73. doi: 10.1067/mob.2002.121541.
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Congenital syphilis.先天性梅毒
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