Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Division of Dental, Department of Clinical Practice and Support, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima City, 734-8551, Japan.
Sci Rep. 2022 Mar 28;12(1):5284. doi: 10.1038/s41598-022-09192-y.
Peri-implantitis has a polymicrobial etiology and is a major cause of dental implant loss. Various clinical protocols for its prevention and treatment have been proposed; however, some cases show a rapid progression with non-resolving clinical symptoms. To clear a means of differentiating between such cases, the implants with peri-implantitis in this study were categorized as the active group and the remission group and that two kinds of samples were obtained from the same subjects (n = 20). The microbiome was analyzed through pyrosequencing of the 16S rRNA gene. From LEfSe results, Porphyomonas, Fusobacterium, Treponema, Tannerella, and other periodontal pathogens were abundant in the active group, while lactic acid bacteria (Lactobacillales and Bifidobacterium) were abundant in the remission group.
种植体周围炎的病因具有多微生物性，是导致种植牙丧失的主要原因。目前已经提出了各种预防和治疗的临床方案，但有些病例表现出快速进展且临床症状无法缓解。为了找到一种区分这些病例的方法，本研究将种植体周围炎的种植体分为活动组和缓解组，从同一患者（n=20）中获得两种类型的样本。通过 16S rRNA 基因的焦磷酸测序对微生物组进行分析。从 LEfSe 结果来看，活跃组富含卟啉单胞菌、梭杆菌、密螺旋体、丹毒丝菌等牙周致病菌，缓解组则富含乳酸杆菌（乳杆菌科和双歧杆菌）。
