Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.
CRUK Beatson Institute, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Dis Model Mech. 2022 Mar 1;15(3). doi: 10.1242/dmm.049332. Epub 2022 Mar 28.
Whole-body health relies on complex inter-organ signalling networks that enable organisms to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine plays a major role as a signalling centre by producing local and systemic signals that are relayed to the body and that maintain intestinal and organismal homeostasis. Consequently, disruption of intestinal homeostasis and signalling are associated with systemic diseases and multi-organ dysfunction. In recent years, the fruit fly Drosophila melanogaster has emerged as a prime model organism to study tissue-intrinsic and systemic signalling networks of the adult intestine due to its genetic tractability and functional conservation with mammals. In this Review, we highlight Drosophila research that has contributed to our understanding of how the adult intestine interacts with its microenvironment and with distant organs. We discuss the implications of these findings for understanding intestinal and whole-body pathophysiology, and how future Drosophila studies might advance our knowledge of the complex interplay between the intestine and the rest of the body in health and disease.
全身健康依赖于复杂的器官间信号网络，使生物体能够适应环境干扰和组织内稳态的变化。肠道通过产生局部和全身信号，传递到全身，并维持肠道和机体的内稳态，在信号中心发挥主要作用。因此，肠道内稳态和信号的破坏与全身疾病和多器官功能障碍有关。近年来，果蝇 Drosophila melanogaster 由于其遗传易操作性和与哺乳动物的功能保守性，已成为研究成年肠道固有和系统信号网络的主要模式生物。在这篇综述中，我们强调了果蝇研究如何有助于我们理解成年肠道如何与其微环境和远处的器官相互作用。我们讨论了这些发现对理解肠道和全身生理学的意义，以及未来的果蝇研究如何增进我们对健康和疾病中肠道与身体其他部位之间复杂相互作用的认识。
