Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Department of Obstetrics & Gynecology, C.S. Mott Center for Human growth and Development, School of Medicine, Wayne State University, Detroit, Michigan, USA.
Transl Res. 2022 Aug;246:102-114. doi: 10.1016/j.trsl.2022.03.009. Epub 2022 Mar 26.
Electronic cigarette (e-cig) use has increased over the past decade, and exposure to e-cig aerosols during pregnancy raises concern for maternal and fetal health. The developing fetal lung is known to be sensitive to prenatal tobacco product exposure. Utilizing a 3-pronged approach, we examined the effects of prenatal e-cig aerosols with, and without nicotine on respiratory development in a murine model. RNAseq analysis of fetal lungs revealed extensive dysregulation in gene expression. Morphologic assessment of distal airspaces in neonatal lungs display an emphysematic phenotype. Respiratory mechanics of neonates display signs of increased respiratory workload, with increased resistance and decreased compliance. These data are novel and provide evidence that prenatal e-cig exposure may result in altered lung function or development of disease.
电子烟（e-cig）的使用在过去十年中有所增加，怀孕期间暴露于电子烟气溶胶引起了人们对母婴健康的关注。众所周知，发育中的胎儿肺对产前烟草制品暴露敏感。我们采用三管齐下的方法，在小鼠模型中研究了产前电子烟气溶胶及其含尼古丁和不含尼古丁对呼吸发育的影响。胎儿肺的 RNAseq 分析显示基因表达广泛失调。新生肺远端气道的形态学评估显示出肺气肿表型。新生儿的呼吸力学显示出增加呼吸工作量的迹象，阻力增加，顺应性降低。这些数据是新颖的，为产前电子烟暴露可能导致肺功能改变或疾病发展提供了证据。
