La Vaccara V, Cammarata R, Coppola A, Farolfi T, Cascone C, Angeletti S, Maltese G, Coppola R, Caputo D
General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Rome 00128, Italy.
Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, Rome 00128, Italy.
Data Brief. 2022 Mar 18;42:108064. doi: 10.1016/j.dib.2022.108064. eCollection 2022 Jun.
Pancreatic surgery is one of the surgeries burdened with the highest mortality and morbidity rate. This is due both to the aggressive biological nature of the pathology affecting the organ and to the technical difficulties associated with surgery. A further aspect on which research is focusing is represented by inflammation related to oncological pathology. Inflammation plays an important role in tumor progression, and growing evidence has confirmed that the fibrinogen-to-albumin ratio (FAR) is an important prognostic factor for overall survival (OS) in malignant tumors. Inflammatory markers had demonstrated also a role in the prediction of postoperative complication after pancreatic surgery. We speculate that FAR, as an easily available, cost-effective, and non-invasive prognostic indicator for pancreatic cancer patients, could help to identify patients at increased risk of postoperative pancreatic fistula (POPF). We therefore retrospectively analyzed the data relating to 117 pancreatic resections relating direct and indirect markers of inflammation with the incidence of post-operative complications.
胰腺手术是死亡率和发病率最高的手术之一。这既是由于影响该器官的病理的侵袭性生物学特性，也是由于与手术相关的技术困难。研究关注的另一个方面是与肿瘤病理相关的炎症。炎症在肿瘤进展中起重要作用，越来越多的证据证实纤维蛋白原与白蛋白比值（FAR）是恶性肿瘤总生存期（OS）的重要预后因素。炎症标志物在预测胰腺手术后的术后并发症方面也发挥了作用。我们推测，FAR作为一种易于获得、成本效益高且非侵入性的胰腺癌患者预后指标，可能有助于识别术后胰瘘（POPF）风险增加的患者。因此，我们回顾性分析了117例胰腺切除术的数据，将炎症的直接和间接标志物与术后并发症的发生率相关联。
