Department G.F Ingrassia, Unit of Otolaryngology, University of Catania, Catania, Italy.
Eur Rev Med Pharmacol Sci. 2022 Mar;26(6):2196-2200. doi: 10.26355/eurrev_202203_28368.
COVID-19 has been associated with a wide range of quantitative and qualitative disorders of smell, including hyposmia/anosmia, parosmia, and phantosmia; however, no reports to date have reported hyperosmia as a sequela of SARS-CoV-2 infection.
We present two cases of subjective hyperosmia in a South Tyrolean Alps family, occurring within days after recovery from SARS-CoV-2 infection with transient anosmia.
The subjects, a mother and son, exhibited subjective hyperosmia despite normal objective olfactory testing. During independent assessments, the severity of hyperosmia and specific odors affected were highly correlated, consistent with shared genetic and environmental factors. In contrast, two other family members with COVID-19 had no perceptual distortion and normal recovery of smell.
Subjective hyperosmia after COVID-19 infection exhibited striking similarity in two affected family members, suggesting interaction of environment, genetics, and perception.
COVID-19 与广泛的嗅觉定量和定性障碍有关，包括嗅觉减退/嗅觉丧失、嗅觉倒错和幻嗅；然而，迄今为止尚无报告称 SARS-CoV-2 感染后会出现嗅觉过敏。
我们报告了一对来自南蒂罗尔阿尔卑斯山的家庭中的两例主观嗅觉过敏病例，这些病例在 SARS-CoV-2 感染后恢复期间出现短暂的嗅觉丧失后几天内发生。
尽管客观嗅觉测试正常，但这两位受试者，一位母亲和一位儿子，均表现出主观嗅觉过敏。在独立评估中，嗅觉过敏的严重程度和受影响的特定气味高度相关，这与共同的遗传和环境因素一致。相比之下，另外两名患有 COVID-19 的家庭成员没有感知扭曲，嗅觉也恢复正常。
COVID-19 感染后的主观嗅觉过敏在两名受影响的家庭成员中表现出惊人的相似性，提示环境、遗传和感知之间的相互作用。
