Zeng Zeng, Gao Huali, Chen CongXian, Xiao Lianbo, Zhang Kun
Orthopedic Surgery Department, Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Front Chem. 2022 Mar 18;10:881812. doi: 10.3389/fchem.2022.881812. eCollection 2022.
Cancer is a serious health problem which increasingly causes morbidity and mortality worldwide. It causes abnormal and uncontrolled cell division. Traditional cancer treatments include surgery, chemotherapy, radiotherapy and so on. These traditional therapies suffer from high toxicity and arouse safety concern in normal area and have difficulty in accurately targeting tumour. Recently, a variety of nanomaterials could be used for cancer diagnosis and therapy. Nanomaterials have several advantages, , high concentration in tumour via targeting design, reduced toxicity in normal area and controlled drug release after various rational designs. They can combine with many types of biomaterials in order to improve biocompatibility. In this review, we outlined the latest research on the use of bioresponsive nanomaterials for various cancer imaging modalities (magnetic resonance imaging, positron emission tomography and phototacoustic imaging) and imaging-guided therapy means (chemotherapy, radiotherapy, photothermal therapy and photodynamic therapy), followed by discussing the challenges and future perspectives of this bioresponsive nanomaterials in biomedicine.
癌症是一个严重的健康问题，在全球范围内导致发病率和死亡率不断上升。它会引发异常且不受控制的细胞分裂。传统的癌症治疗方法包括手术、化疗、放疗等。这些传统疗法具有高毒性，会引发正常组织的安全担忧，并且难以精确靶向肿瘤。近年来，多种纳米材料可用于癌症诊断和治疗。纳米材料具有多种优势，例如通过靶向设计在肿瘤中实现高浓度富集、降低在正常组织中的毒性以及经过各种合理设计后实现药物的可控释放。它们可以与多种类型的生物材料结合以提高生物相容性。在本综述中，我们概述了生物响应性纳米材料在各种癌症成像模式（磁共振成像、正电子发射断层扫描和光声成像）以及成像引导治疗手段（化疗、放疗、光热疗法和光动力疗法）方面的最新研究，随后讨论了这种生物响应性纳米材料在生物医学中的挑战和未来前景。
