• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与免疫球蛋白基因启动子/增强子元件密切相关的序列也存在于其他真核基因和原核基因的上游。

Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genes.

作者信息

Falkner F G, Mocikat R, Zachau H G

出版信息

Nucleic Acids Res. 1986 Nov 25;14(22):8819-27. doi: 10.1093/nar/14.22.8819.

DOI:10.1093/nar/14.22.8819
PMID:3537963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC311913/
Abstract

Decanucleotide sequences closely related to the TNATTTGCAT element which occurs upstream of the immunoglobulin genes and in the immunoglobulin gene enhancer were found also upstream of other eukaryotic and of prokaryotic genes. The possibility of evolutionary and functional relationships between the various transcriptional systems is discussed.

摘要

在免疫球蛋白基因上游以及免疫球蛋白基因增强子中出现的与TNATTTGCAT元件密切相关的十核苷酸序列，也在其他真核基因和原核基因的上游被发现。文中讨论了各种转录系统之间存在进化和功能关系的可能性。

相似文献

1
Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genes.与免疫球蛋白基因启动子/增强子元件密切相关的序列也存在于其他真核基因和原核基因的上游。
Nucleic Acids Res. 1986 Nov 25;14(22):8819-27. doi: 10.1093/nar/14.22.8819.
2
Upstream regulatory sequences of immunoglobulin genes are recognized by nuclear proteins which also bind to other gene regions.免疫球蛋白基因的上游调控序列可被一些核蛋白识别，这些核蛋白也能与其他基因区域结合。
Nucleic Acids Res. 1986 Nov 25;14(22):8829-44. doi: 10.1093/nar/14.22.8829.
3
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.一种与免疫球蛋白基因转录控制元件中的保守序列基序结合的核因子。
Nature. 1986;319(6049):154-8. doi: 10.1038/319154a0.
4
Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes.一种常见因子与组蛋白H2B、免疫球蛋白和U2小核RNA（snRNA）基因中保守的启动子和增强子序列的相互作用。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6382-6. doi: 10.1073/pnas.83.17.6382.
5
[Screening and application of prokaryotic enhancer-like sequence 3A].[原核生物类增强子序列3A的筛选与应用]
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Jun;24(3):175-7.
6
Similarities between prokaryotic and eukaryotic cyclic AMP-responsive promoter elements.原核生物和真核生物环磷酸腺苷反应性启动子元件之间的相似性。
Nature. 1989 Aug 24;340(6235):656-9. doi: 10.1038/340656a0.
7
Yeast HIS3 expression in Escherichia coli depends upon fortuitous homology between eukaryotic and prokaryotic promoter elements.酵母HIS3基因在大肠杆菌中的表达取决于真核和原核启动子元件之间的偶然同源性。
J Mol Biol. 1986 Sep 20;191(2):221-9. doi: 10.1016/0022-2836(86)90259-7.
8
Modulation of transcriptional activity of the chicken ovalbumin gene promoter in primary cultures of chicken oviduct cells: effects of putative regulatory elements in the 5'-flanking region.鸡输卵管细胞原代培养中鸡卵清蛋白基因启动子转录活性的调控：5'-侧翼区假定调控元件的作用
Biochem Mol Biol Int. 1995 Jul;36(4):811-6.
9
Upstream and downstream control of eukaryotic genes.
Nature. 1984;312(5996):700-1. doi: 10.1038/312700a0.
10
Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element.人类金属硫蛋白-IIA基因的上游启动子元件可发挥增强子元件的作用。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8572-6. doi: 10.1073/pnas.82.24.8572.

引用本文的文献

1
The TAATGARAT motif in the herpes simplex virus immediate-early gene promoters can confer both positive and negative responses to cellular octamer-binding proteins when it is located within the viral genome.单纯疱疹病毒立即早期基因启动子中的TAATGARAT基序位于病毒基因组内时，可对细胞八聚体结合蛋白产生正向和负向反应。
J Virol. 1998 Apr;72(4):3495-500. doi: 10.1128/JVI.72.4.3495-3500.1998.
2
Direct evidence that the POU family transcription factor Oct-2 represses the cellular tyrosine hydroxylase gene in neuronal cells.POU家族转录因子Oct-2抑制神经元细胞中细胞酪氨酸羟化酶基因的直接证据。
J Mol Neurosci. 1995;6(3):159-67. doi: 10.1007/BF02736762.
3
Characterization of a Marek's disease virus BamHI-L-specific cDNA clone obtained from a Marek's disease lymphoblastoid cell line.从马立克氏病淋巴母细胞系获得的马立克氏病病毒BamHI-L特异性cDNA克隆的鉴定
J Virol. 1994 Feb;68(2):1191-5. doi: 10.1128/JVI.68.2.1191-1195.1994.
4
Analysis of the imperfect octamer-containing human immunoglobulin VH6 gene promoter.含不完全八聚体的人免疫球蛋白VH6基因启动子分析。
Nucleic Acids Res. 1994 Mar 11;22(5):850-60. doi: 10.1093/nar/22.5.850.
5
Upstream regulatory sequences of immunoglobulin genes are recognized by nuclear proteins which also bind to other gene regions.免疫球蛋白基因的上游调控序列可被一些核蛋白识别，这些核蛋白也能与其他基因区域结合。
Nucleic Acids Res. 1986 Nov 25;14(22):8829-44. doi: 10.1093/nar/14.22.8829.
6
Lysozyme gene activity in chicken macrophages is controlled by positive and negative regulatory elements.鸡巨噬细胞中溶菌酶基因的活性受正调控元件和负调控元件的控制。
Nucleic Acids Res. 1987 May 26;15(10):4163-78. doi: 10.1093/nar/15.10.4163.
7
Conservation of histone H2A/H2B intergene regions: a role for the H2B specific element in divergent transcription.组蛋白H2A/H2B基因间区域的保守性：H2B特异性元件在差异转录中的作用。
Nucleic Acids Res. 1988 Sep 12;16(17):8571-86. doi: 10.1093/nar/16.17.8571.
8
Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo.转录因子与雌激素诱导的载脂蛋白VLDL II启动子在体内的组织特异性和类固醇依赖性相互作用。
EMBO J. 1988 Sep;7(9):2757-63. doi: 10.1002/j.1460-2075.1988.tb03130.x.
9
Purified mu EBP-E binds to immunoglobulin enhancers and promoters.纯化的μEBP-E与免疫球蛋白增强子和启动子结合。
Mol Cell Biol. 1988 Nov;8(11):4972-80. doi: 10.1128/mcb.8.11.4972-4980.1988.
10
Nuclear factor NF-kappa B can interact functionally with its cognate binding site to provide lymphoid-specific promoter function.核因子NF-κB可与其同源结合位点发生功能性相互作用，以提供淋巴细胞特异性启动子功能。
EMBO J. 1988 Oct;7(10):3109-13. doi: 10.1002/j.1460-2075.1988.tb03177.x.

本文引用的文献

1
Cloning of a gene localized and expressed at the ecdysteroid regulated puff 74EF in salivary glands of Drosophila larvae.克隆一个在果蝇幼虫唾腺中受蜕皮激素调控的 74EF 膨突特异表达和定位的基因。
EMBO J. 1984 Feb;3(2):289-95. doi: 10.1002/j.1460-2075.1984.tb01798.x.
2
Similar amino acid sequences: chance or common ancestry?相似的氨基酸序列：偶然因素还是共同祖先？
Science. 1981 Oct 9;214(4517):149-59. doi: 10.1126/science.7280687.
3
Primary structure of the histone H2A and H2B genes and their flanking sequences in a minor histone gene cluster of Xenopus laevis.非洲爪蟾一个小的组蛋白基因簇中组蛋白H2A和H2B基因的一级结构及其侧翼序列
FEBS Lett. 1982 Aug 2;144(2):235-41. doi: 10.1016/0014-5793(82)80645-5.
4
Very short repeats and coordinate induction of genes.极短重复序列与基因的协同诱导
Nature. 1983 Feb 10;301(5900):468-70. doi: 10.1038/301468a0.
5
Diversity of germ-line immunoglobulin VH genes.种系免疫球蛋白VH基因的多样性。
Nature. 1981 Jul 30;292(5822):426-30. doi: 10.1038/292426a0.
6
Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma.小鼠骨髓瘤免疫球蛋白轻链基因中的功能性和非功能性连接
Nature. 1980 Oct 16;287(5783):603-7. doi: 10.1038/287603a0.
7
Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes.相同胚胎和浆细胞瘤κ轻链可变区基因的组织与完整序列
J Biol Chem. 1980 Apr 25;255(8):3691-4.
8
Two regulatory elements for immunoglobulin kappa light chain gene expression.免疫球蛋白κ轻链基因表达的两个调控元件。
Proc Natl Acad Sci U S A. 1984 Nov;81(22):7041-5. doi: 10.1073/pnas.81.22.7041.
9
Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.免疫球蛋白基因5'端的结构：一种新的保守序列。
Proc Natl Acad Sci U S A. 1984 May;81(9):2650-4. doi: 10.1073/pnas.81.9.2650.
10
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.一种淋巴细胞特异性细胞增强子位于免疫球蛋白重链基因连接区的下游。
Cell. 1983 Jul;33(3):729-40. doi: 10.1016/0092-8674(83)90015-6.