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A Traditional Chinese Medicine Syndrome Classification Model Based on Cross-Feature Generation by Convolution Neural Network: Model Development and Validation.

作者信息

Huang Zonghai, Miao Jiaqing, Chen Ju, Zhong Yanmei, Yang Simin, Ma Yiyi, Wen Chuanbiao

机构信息

College of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

School of Mathematics, Southwest Minzu University, Chengdu, China.

出版信息

JMIR Med Inform. 2022 Apr 6;10(4):e29290. doi: 10.2196/29290.


DOI:10.2196/29290
PMID:35384854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9021949/
Abstract

BACKGROUND: Nowadays, intelligent medicine is gaining widespread attention, and great progress has been made in Western medicine with the help of artificial intelligence to assist in decision making. Compared with Western medicine, traditional Chinese medicine (TCM) involves selecting the specific treatment method, prescription, and medication based on the dialectical results of each patient's symptoms. For this reason, the development of a TCM-assisted decision-making system has lagged. Treatment based on syndrome differentiation is the core of TCM treatment; TCM doctors can dialectically classify diseases according to patients' symptoms and optimize treatment in time. Therefore, the essence of a TCM-assisted decision-making system is a TCM intelligent, dialectical algorithm. Symptoms stored in electronic medical records are mostly associated with patients' diseases; however, symptoms of TCM are mostly subjectively identified. In general electronic medical records, there are many missing values. TCM medical records, in which symptoms tend to cause high-dimensional sparse data, reduce algorithm accuracy. OBJECTIVE: This study aims to construct an algorithm model compatible for the multidimensional, highly sparse, and multiclassification task of TCM syndrome differentiation, so that it can be effectively applied to the intelligent dialectic of different diseases. METHODS: The relevant terms in electronic medical records were standardized with respect to symptoms and evidence-based criteria of TCM. We structuralized case data based on the classification of different symptoms and physical signs according to the 4 diagnostic examinations in TCM diagnosis. A novel cross-feature generation by convolution neural network model performed evidence-based recommendations based on the input embedded, structured medical record data. RESULTS: The data set included 5273 real dysmenorrhea cases from the Sichuan TCM big data management platform and the Chinese literature database, which were embedded into 60 fields after being structured and standardized. The training set and test set were randomly constructed in a ratio of 3:1. For the classification of different syndrome types, compared with 6 traditional, intelligent dialectical models and 3 click-through-rate models, the new model showed a good generalization ability and good classification effect. The comprehensive accuracy rate reached 96.21%. CONCLUSIONS: The main contribution of this study is the construction of a new intelligent dialectical model combining the characteristics of TCM by treating intelligent dialectics as a high-dimensional sparse vector classification task. Owing to the standardization of the input symptoms, all the common symptoms of TCM are covered, and the model can differentiate the symptoms with a variety of missing values. Therefore, with the continuous improvement of disease data sets, this model has the potential to be applied to the dialectical classification of different diseases in TCM.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/64ba40d6140d/medinform_v10i4e29290_fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/694ee6254619/medinform_v10i4e29290_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/1804fc38817b/medinform_v10i4e29290_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/ff2b438651ad/medinform_v10i4e29290_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/b0000b76e8e2/medinform_v10i4e29290_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/a92a82c676f2/medinform_v10i4e29290_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/816863c1e146/medinform_v10i4e29290_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/6625ea178347/medinform_v10i4e29290_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/de93fd8b13aa/medinform_v10i4e29290_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/79b5281e37b2/medinform_v10i4e29290_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/64ba40d6140d/medinform_v10i4e29290_fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/694ee6254619/medinform_v10i4e29290_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/1804fc38817b/medinform_v10i4e29290_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/ff2b438651ad/medinform_v10i4e29290_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/b0000b76e8e2/medinform_v10i4e29290_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/a92a82c676f2/medinform_v10i4e29290_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/816863c1e146/medinform_v10i4e29290_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/6625ea178347/medinform_v10i4e29290_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/de93fd8b13aa/medinform_v10i4e29290_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/79b5281e37b2/medinform_v10i4e29290_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95f1/9021949/64ba40d6140d/medinform_v10i4e29290_fig10.jpg

相似文献

[1]
A Traditional Chinese Medicine Syndrome Classification Model Based on Cross-Feature Generation by Convolution Neural Network: Model Development and Validation.

JMIR Med Inform. 2022-4-6

[2]
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[3]
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[4]
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[6]
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[7]
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引用本文的文献

[1]
Integrating Traditional Nutritional Wisdom into Digital Nutrition Platforms: Toward Culturally Adaptive and Inclusive Health Technologies.

Nutrients. 2025-6-11

[2]
Digital intelligence technology: new quality productivity for precision traditional Chinese medicine.

Front Pharmacol. 2025-4-8

[3]
Predicting TCM patterns in PCOS patients: An exploration of feature selection methods and multi-label machine learning models.

Heliyon. 2024-7-26

[4]
AI: Bridging Ancient Wisdom and Modern Innovation in Traditional Chinese Medicine.

JMIR Med Inform. 2024-6-28

[5]
Traditional Chinese herbal formulas modulate gut microbiome and improve insomnia in patients with distinct syndrome types: insights from an interventional clinical study.

Front Cell Infect Microbiol. 2024

[6]
Traditional Chinese medicine diagnostic prediction model for holistic syndrome differentiation based on deep learning.

Integr Med Res. 2024-3

[7]
Current status and trends of artificial intelligence research on the four traditional Chinese medicine diagnostic methods: a scientometric study.

Ann Transl Med. 2023-2-15

本文引用的文献

[1]
Prevalence, risk factors, and management practices of primary dysmenorrhea among young females.

BMC Womens Health. 2021-11-8

[2]
Study of TCM Syndrome Identification Modes for Patients with Type 2 Diabetes Mellitus Based on Data Mining.

Evid Based Complement Alternat Med. 2021-9-6

[3]
Network differentiation: A computational method of pathogenesis diagnosis in traditional Chinese medicine based on systems science.

Artif Intell Med. 2021-8

[4]
Research on Diagnosis Prediction of Traditional Chinese Medicine Diseases Based on Improved Bayesian Combination Model.

Evid Based Complement Alternat Med. 2021-6-10

[5]
The Effectiveness of Traditional Chinese Medicine (TCM) as an Adjunct Treatment on Stable COPD Patients: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med. 2021-6-4

[6]
Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes.

Biomed Pharmacother. 2021-5

[7]
Traditional Chinese Medicine Treatment Associated with Female Infertility in Taiwan: A Population-Based Case-Control Study.

Evid Based Complement Alternat Med. 2020-12-8

[8]
A systematic review of the efficacy comparison of acupuncture and traditional Chinese medicine in the treatment of primary dysmenorrhea.

Ann Palliat Med. 2020-9

[9]
Living with Pain and Looking for a Safe Environment: A Qualitative Study among Nursing Students with Dysmenorrhea.

Int J Environ Res Public Health. 2020-9-13

[10]
Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.

J Tradit Chin Med. 2020-8

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