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Analgesia in the acute abdomen.急腹症的镇痛
Ann R Coll Surg Engl. 1986 Jul;68(4):209-10.
2
Transdermal buprenorphine in the treatment of chronic pain: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study.透皮丁丙诺啡治疗慢性疼痛：一项III期、多中心、随机、双盲、安慰剂对照研究的结果
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Pain relief after major abdominal surgery: a double-blind controlled comparison of sublingual buprenorphine, intramuscular buprenorphine, and intramuscular meperidine.腹部大手术后的疼痛缓解：舌下含服丁丙诺啡、肌肉注射丁丙诺啡和肌肉注射哌替啶的双盲对照比较。
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Buprenorphine transdermal delivery system in adults with persistent noncancer-related pain syndromes who require opioid therapy: a multicenter, 5-week run-in and randomized, double-blind maintenance-of-analgesia study.丁丙诺啡透皮给药系统用于需要阿片类药物治疗的持续性非癌性疼痛综合征成人患者：一项多中心、为期5周的导入期及随机、双盲镇痛维持研究。
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[A double-blind comparison of epidural buprenorphine and epidural morphine in postoperative pain (author's transl)].
Anasth Intensivther Notfallmed. 1981 Dec;16(6):333-9.
6
Effects of intravenous patient-controlled analgesia with buprenorphine and morphine alone and in combination during the first 12 postoperative hours: a randomized, double-blind, four-arm trial in adults undergoing abdominal surgery.术后12小时内单独及联合使用丁丙诺啡和吗啡静脉自控镇痛的效果：一项针对接受腹部手术的成年人的随机、双盲、四臂试验。
Clin Ther. 2009 Mar;31(3):527-41. doi: 10.1016/j.clinthera.2009.03.018.
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Epidural buprenorphine--a double-blind study of postoperative analgesia and side effects.硬膜外注射丁丙诺啡——术后镇痛及副作用的双盲研究
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Efficacy and safety of transdermal buprenorphine: a randomized, placebo-controlled trial in 289 patients with severe cancer pain.透皮丁丙诺啡的疗效与安全性：一项针对289例重度癌痛患者的随机、安慰剂对照试验。
J Pain Symptom Manage. 2008 Aug;36(2):117-25. doi: 10.1016/j.jpainsymman.2007.09.011. Epub 2008 Apr 14.
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[Analgesic effect and side-effects of buprenorphine in acute coronary heart disease. A randomized double-blind comparison with morphine].[丁丙诺啡在急性冠心病中的镇痛效果及副作用。与吗啡的随机双盲对照研究]
Anasth Intensivther Notfallmed. 1988 Dec;23(6):309-12.
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[Periodic sublingual buprenorphine for pain relief after upper abdominal surgery].[周期性舌下含服丁丙诺啡用于上腹部手术后的疼痛缓解]
Masui. 1989 Apr;38(4):493-7.

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Comparing the effects of pre-emptive oxycodone, diclofenac, and gabapentin on postoperative pain after tibia fracture surgery: A randomized clinical trail.比较术前使用羟考酮、双氯芬酸和加巴喷丁对胫骨骨折手术后疼痛的影响：一项随机临床试验。
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Post-operative Analgesia in Opioid Dependent Patients: Comparison of Intravenous Morphine and Sublingual Buprenorphine.阿片类药物依赖患者的术后镇痛：静脉注射吗啡与舌下含服丁丙诺啡的比较
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An Evaluation of the Effect of Morphine on Abdominal Pain and PeritonealIrritation Signs in Patients with Acute Surgical Abdomen.吗啡对急性外科急腹症患者腹痛及腹膜刺激征影响的评估
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Preoperative pain treatment in acute abdomen in Osogbo, Nigeria: a randomized double-blind placebo-controlled study.尼日利亚奥索博急性腹痛的术前疼痛治疗：一项随机双盲安慰剂对照研究。
Int J Emerg Med. 2013 Jan 23;6(1):3. doi: 10.1186/1865-1380-6-3.
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Analgesia for older adults with abdominal or back pain in emergency department.急诊科老年腹痛或背痛患者的镇痛。
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Analgesia in patients with acute abdominal pain.急性腹痛患者的镇痛
Cochrane Database Syst Rev. 2011 Jan 19;2011(1):CD005660. doi: 10.1002/14651858.CD005660.pub3.
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Analgesia in patients with acute abdomen.急腹症患者的镇痛
West J Med. 2000 Jul;173(1):13. doi: 10.1136/ewjm.173.1.13.
8
Medical myth: Analgesia should not be given to patients with an acute abdomen because it obscures the diagnosis.医学误区：急腹症患者不应给予镇痛治疗，因为这会掩盖诊断。
West J Med. 2000 Mar;172(3):209-10. doi: 10.1136/ewjm.172.3.209.
9
Safety of early pain relief for acute abdominal pain.急性腹痛早期疼痛缓解的安全性。
BMJ. 1992 Sep 5;305(6853):554-6. doi: 10.1136/bmj.305.6853.554.

本文引用的文献

1
Clinical presentation of acute abdomen: study of 600 patients.急腹症的临床表现：600例患者的研究
Br Med J. 1972 Aug 12;3(5823):393-8. doi: 10.1136/bmj.3.5823.393.

急腹症的镇痛

Analgesia in the acute abdomen.

作者信息

Zoltie N, Cust M P

出版信息

Ann R Coll Surg Engl. 1986 Jul;68(4):209-10.

PMID:3538987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2498389/
Abstract

In a prospective sequential double blind trial 288 patients with acute abdominal pain were given sublingual buprenorphine 200 mcg, sublingual buprenorphine 400 mcg, or placebo. Pain relief was proportional to the number of tablets administered; buprenorphine had no difference in effect compared to placebo. Physical signs altered in proportion to dosage, but this had no effect on clinical diagnosis. We conclude that patients with acute abdominal pain may be given buprenorphine without fear of masking the diagnosis.

摘要

在一项前瞻性序贯双盲试验中，288例急性腹痛患者分别接受200微克舌下丁丙诺啡、400微克舌下丁丙诺啡或安慰剂治疗。疼痛缓解程度与给药片数成正比；丁丙诺啡与安慰剂相比效果无差异。体征变化与剂量成正比，但这对临床诊断没有影响。我们得出结论，急性腹痛患者可以使用丁丙诺啡，而不必担心掩盖诊断。