Disinfection Division, H. Ikeuchi & Co., Ltd., Nishiwaki, Hyogo, Japan.
Division of Global Infectious Diseases, Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan.
PLoS One. 2022 Apr 7;17(4):e0261802. doi: 10.1371/journal.pone.0261802. eCollection 2022.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is transmitted mainly by droplet or aerosol infection; however, it may also be transmitted by contact infection. SARS-CoV-2 that adheres to environmental surfaces remains infectious for several days. We herein attempted to inactivate SARS-CoV-2 and influenza A virus adhering to an environmental surface by dry fogging hypochlorous acid solution and hydrogen peroxide solution. SARS-CoV-2 and influenza virus were air-dried on plastic plates and placed into a test chamber for inactivation by the dry fogging of these disinfectants. The results obtained showed that the dry fogging of hypochlorous acid solution and hydrogen peroxide solution inactivated SARS-CoV-2 and influenza A virus in CT value (the product of the disinfectant concentration and contact time)-dependent manners. SARS-CoV-2 was more resistant to the virucidal effects of aerosolized hypochlorous acid solution and hydrogen peroxide solution than influenza A virus; therefore, higher concentrations of disinfectants or longer contact times were required to inactivate SARS-CoV-2 than influenza A virus. The present results provide important information for the development of a strategy that inactivates SARS-CoV-2 and influenza A virus on environmental surfaces by spatial fogging.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是导致 2019 年冠状病毒病（COVID-19）的病原体，主要通过飞沫或气溶胶感染传播；然而，它也可能通过接触感染传播。附着在环境表面上的 SARS-CoV-2 可在数天内保持传染性。本研究试图通过干雾形式的次氯酸溶液和过氧化氢溶液灭活附着在环境表面上的 SARS-CoV-2 和甲型流感病毒。将 SARS-CoV-2 和流感病毒在塑料板上风干，然后将其放入测试室中，通过这些消毒剂的干雾处理来进行灭活。结果表明，次氯酸溶液和过氧化氢溶液的干雾以 CT 值（消毒剂浓度与接触时间的乘积）依赖性方式使 SARS-CoV-2 和甲型流感病毒失活。与甲型流感病毒相比，气溶胶形式的次氯酸溶液和过氧化氢溶液对 SARS-CoV-2 的病毒杀灭作用更具抵抗力；因此，需要更高浓度的消毒剂或更长的接触时间才能使 SARS-CoV-2 失活，而不是甲型流感病毒。本研究结果为通过空间喷雾灭活环境表面上的 SARS-CoV-2 和甲型流感病毒提供了重要信息。
