Adibi Shawn S, Hanson Ryan, Fray David F, Abedi Tania, Neil Brianna, Maher Danielle, Tribble Gena, Warner Ben F, Farach-Carson Mary C
Professor, Department of General Practice and Dental Public Health, The University of Texas at Houston, School of Dentistry, Houston, TX, USA.
Senior Scientist, ARKRAY INC., Edina, MN, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Jun;133(6):663-674. doi: 10.1016/j.oooo.2022.02.007. Epub 2022 Feb 23.
The study evaluated use of a multipoint saliva analyzer to assess patient wellness in a contemporary dental practice setting.
Unstimulated saliva from a diverse 104 patient cohort was analyzed using the SillHa Oral Wellness System. The device measures the following 7 analytes present in the patient's oral rinse: cariogenic bacteria, acidity, buffer capacity, blood, leukocytes, protein, and ammonia. Data obtained were compared with validated clinical assessment data independently provided by credentialed dental professionals.
Measured leukocyte and protein levels were higher in patients with periodontal disease and/or deep gingival pockets. Patients with a history of cancer and/or diabetes presented with higher ammonia and lower leukocyte levels. Acidity levels were higher in patients using multiple xerogenic medications and lower in patients with a history of sleep apnea. Sex differences showed female patients exhibiting higher acidity, lower buffer capacity, and lower ammonia than male patients. Increasing age is associated with elevated buffer capacity.
Multipoint saliva analyzers such as the one used in this study, along with clinical practice examination and medical history, can provide rapid salivary component analysis that augments treatment planning. A follow-up multisite study would provide the opportunity to test this analyzer in clinical sites with different practice workflows.
本研究评估了在当代牙科诊所环境中使用多点唾液分析仪评估患者健康状况的情况。
使用SillHa口腔健康系统对来自104名不同患者队列的非刺激性唾液进行分析。该设备可测量患者漱口液中存在的以下7种分析物：致龋菌、酸度、缓冲能力、血液、白细胞、蛋白质和氨。将获得的数据与有资质的牙科专业人员独立提供的经过验证的临床评估数据进行比较。
牙周病和/或深牙龈袋患者的白细胞和蛋白质水平测量值较高。有癌症和/或糖尿病病史的患者氨水平较高，白细胞水平较低。使用多种致口干药物的患者酸度水平较高，有睡眠呼吸暂停病史的患者酸度水平较低。性别差异显示，女性患者的酸度高于男性患者，缓冲能力和氨水平低于男性患者。年龄增长与缓冲能力升高有关。
本研究中使用的此类多点唾液分析仪，连同临床实践检查和病史，可以提供快速的唾液成分分析，辅助治疗计划的制定。一项后续的多地点研究将提供机会在不同实践工作流程的临床场所测试该分析仪。
